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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Levothyroxine and Quality of Life
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<blockquote data-quote="CoastWatcher" data-source="post: 102410" data-attributes="member: 2624"><p><strong>Adults with hypothyroidism prescribed levothyroxine were more likely to experience lower health-related quality of life and increased comorbidities when compared with similar adults not prescribed thyroid hormone therapy. </strong></p><p></p><p></p><ul> <li data-xf-list-type="ul"><strong><em>“Hypothyroidism is a common endocrine disorder, and substitution therapy with <a href="https://www.healio.com/endocrinology/bone-mineral-metabolism/news/in-the-journals/%7bb0a975dd-c1d7-4802-bb25-19f14f84fcec%7d/fracture-incidence-in-thyroid-cancer-linked-to-levothyroxine-dose" target="_blank">levothyroxine</a> is the standard of care,” Hanneke Wouters of University Medical Center Groningen, Netherlands, said during an oral abstract presentation at the Endocrine Society Annual Meeting. “Unfortunately, about 10% of the individuals using this drug continue to experience symptoms and a disturbed wellbeing and a disturbed quality of life, despite the fact that their [thyroid-stimulating hormone] level is within the normal range, so they are euthyroid.”</em></strong></li> </ul><p></p><p></p><ul> <li data-xf-list-type="ul">Wouters and colleagues analyzed data from 34,400 adults with thyroid function measurements participating in the population-based Dutch Lifelines cohort.</li> </ul><p></p><ul> <li data-xf-list-type="ul"></li> <li data-xf-list-type="ul">Within the cohort, 995 adults (2.8% of total cohort) were prescribed levothyroxine. Compared with the population not prescribed levothyroxine, these patients were more likely to be women (89.4% vs. 57.9%), older (mean age, 51 years vs. 45 years), have higher BMI (mean, 27.2 kg/m² vs. 26.1 kg/m²) and use more medications (range, 0-4 vs. 0-2). Patients prescribed levothyroxine were also more likely to have a comorbidity vs. those not prescribed the drug (80.6% vs. 66%).</li> <li data-xf-list-type="ul"></li> <li data-xf-list-type="ul">Among those prescribed levothyroxine, 60% had a normal thyroid-stimulating hormone level (0.4-4 mU/L), 13.4% had TSH defined as suppressed (< 0.4 mU/L) and 26.6% had elevated TSH (at least 4 mU/L)</li> <li data-xf-list-type="ul"></li> <li data-xf-list-type="ul"><strong>Researchers found that patients prescribed levothyroxine had lower scores in all health-related quality-of-life domains, apart from emotional functioning, when compared with patients not on levothyroxine therapy (<em>P < </em>.001 for all). There were no between-group differences in health-related quality of life among patients prescribed levothyroxine therapy when stratified by TSH level or by levels of FT[SUB]<span style="font-size: 10px">3</span>[/SUB] and FT[SUB]<span style="font-size: 10px">4.</span>[/SUB]</strong></li> </ul><p>[SUB]<span style="font-size: 10px"><span style="font-size: 12px"></span></span></p><p><span style="font-size: 10px"><span style="font-size: 12px">"Levothyroxine therapy associated with lower quality of life in hypothyroidism</span>,</span>[/SUB] <em>Helio, 22 March 2018, <a href="https://www.healio.com/endocrinology/thyroid/news/online/%7Beb193222-2795-4321-8761-607131d2f743%7D/levothyroxine-therapy-associated-with-lower-quality-of-life-in-hypothyroidism" target="_blank">https://www.healio.com/endocrinology/thyroid/news/online/{eb193222-2795-4321-8761-607131d2f743}/levothyroxine-therapy-associated-with-lower-quality-of-life-in-hypothyroidism</a></em></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 102410, member: 2624"] [B]Adults with hypothyroidism prescribed levothyroxine were more likely to experience lower health-related quality of life and increased comorbidities when compared with similar adults not prescribed thyroid hormone therapy. [/B] [LIST] [*][B][I]“Hypothyroidism is a common endocrine disorder, and substitution therapy with [URL="https://www.healio.com/endocrinology/bone-mineral-metabolism/news/in-the-journals/%7bb0a975dd-c1d7-4802-bb25-19f14f84fcec%7d/fracture-incidence-in-thyroid-cancer-linked-to-levothyroxine-dose"]levothyroxine[/URL] is the standard of care,” Hanneke Wouters of University Medical Center Groningen, Netherlands, said during an oral abstract presentation at the Endocrine Society Annual Meeting. “Unfortunately, about 10% of the individuals using this drug continue to experience symptoms and a disturbed wellbeing and a disturbed quality of life, despite the fact that their [thyroid-stimulating hormone] level is within the normal range, so they are euthyroid.”[/I][/B] [/LIST] [LIST] [*]Wouters and colleagues analyzed data from 34,400 adults with thyroid function measurements participating in the population-based Dutch Lifelines cohort. [/LIST] [LIST] [*] [*]Within the cohort, 995 adults (2.8% of total cohort) were prescribed levothyroxine. Compared with the population not prescribed levothyroxine, these patients were more likely to be women (89.4% vs. 57.9%), older (mean age, 51 years vs. 45 years), have higher BMI (mean, 27.2 kg/m² vs. 26.1 kg/m²) and use more medications (range, 0-4 vs. 0-2). Patients prescribed levothyroxine were also more likely to have a comorbidity vs. those not prescribed the drug (80.6% vs. 66%). [*] [*]Among those prescribed levothyroxine, 60% had a normal thyroid-stimulating hormone level (0.4-4 mU/L), 13.4% had TSH defined as suppressed (< 0.4 mU/L) and 26.6% had elevated TSH (at least 4 mU/L) [*] [*][B]Researchers found that patients prescribed levothyroxine had lower scores in all health-related quality-of-life domains, apart from emotional functioning, when compared with patients not on levothyroxine therapy ([I]P < [/I].001 for all). There were no between-group differences in health-related quality of life among patients prescribed levothyroxine therapy when stratified by TSH level or by levels of FT[SUB][SIZE=2]3[/SIZE][/SUB] and FT[SUB][SIZE=2]4.[/SIZE][/SUB][/B] [/LIST] [SUB][SIZE=2][SIZE=3] "Levothyroxine therapy associated with lower quality of life in hypothyroidism[/SIZE],[/SIZE][/SUB] [I]Helio, 22 March 2018, [URL]https://www.healio.com/endocrinology/thyroid/news/online/%7Beb193222-2795-4321-8761-607131d2f743%7D/levothyroxine-therapy-associated-with-lower-quality-of-life-in-hypothyroidism[/URL][/I] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Levothyroxine and Quality of Life
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