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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Left Ventricle Hypertrophy and Nandrolone ( Decadurabolin )
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<blockquote data-quote="SoCal Guy" data-source="post: 77509" data-attributes="member: 14529"><p><strong>Rat study: Rapamycin improved hypertrophy &amp; ejection fraction in rats with early heart failure</strong></p><p></p><p><a href="http://www.ijcem.com/files/ijcem0052684.pdf" target="_blank"><u><strong>Effects of rapamycin on autophagy of myocardial cells in rats with early heart failure</strong></u></a></p><p></p><p><strong>Results</strong>: At 4 weeks after rapamycin intervention, significantly higher left ventricular ejection fraction (LVEF) was observed in the treatment group compared to the control group (P<0.05); but there were substantial reductions in the left ventricular posterior wall thickness at end-systole (LVPWs), the inter-ventricular septum thickness at end-systole (IVSTs), the left ventricular posterior wall thickness atend-diastole (LVPWd) and in the inter-ventricular septal thickness at end-diastole (IVSd) (P<0.05). The autophagy rate of myocardial cells was significantly lower in the treatment group versus the control group (P<0.05). </p><p></p><p>Compared to the sham group, the levels of proteinsBeclin-1 and Cathepsin D expression significantly improved in the control group (P<0.05), but reduced markedly in the treatment group (P<0.05). </p><p></p><p><strong>Conclusion</strong>: Reductions in the autophagy of myocardial cells and improvements in the cardiac functions of rats with heart failure by rapamycin may be attributable to regulation of the expression levels of proteins Beclin-1 and Cathepsin D.</p></blockquote><p></p>
[QUOTE="SoCal Guy, post: 77509, member: 14529"] [b]Rat study: Rapamycin improved hypertrophy & ejection fraction in rats with early heart failure[/b] [URL="http://www.ijcem.com/files/ijcem0052684.pdf"][U][B]Effects of rapamycin on autophagy of myocardial cells in rats with early heart failure[/B][/U][/URL] [B]Results[/B]: At 4 weeks after rapamycin intervention, significantly higher left ventricular ejection fraction (LVEF) was observed in the treatment group compared to the control group (P<0.05); but there were substantial reductions in the left ventricular posterior wall thickness at end-systole (LVPWs), the inter-ventricular septum thickness at end-systole (IVSTs), the left ventricular posterior wall thickness atend-diastole (LVPWd) and in the inter-ventricular septal thickness at end-diastole (IVSd) (P<0.05). The autophagy rate of myocardial cells was significantly lower in the treatment group versus the control group (P<0.05). Compared to the sham group, the levels of proteinsBeclin-1 and Cathepsin D expression significantly improved in the control group (P<0.05), but reduced markedly in the treatment group (P<0.05). [B]Conclusion[/B]: Reductions in the autophagy of myocardial cells and improvements in the cardiac functions of rats with heart failure by rapamycin may be attributable to regulation of the expression levels of proteins Beclin-1 and Cathepsin D. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Left Ventricle Hypertrophy and Nandrolone ( Decadurabolin )
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