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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Left Ventricle Hypertrophy and Nandrolone ( Decadurabolin )
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<blockquote data-quote="SoCal Guy" data-source="post: 59039" data-attributes="member: 14529"><p>The athletic version is not necessarily harmless. It depends on how over-size your ventricle actually is, not whether the cause was steroids or uncontrolled hypertension.</p><p></p><p> The reason is basic physics -- the extra muscle actually <strong>reduces </strong>ejection fraction, because the heart is a <strong>round </strong>muscle. Therefore as the heart gets more muscular, its diameter increases -- which reduces the amount of pumping pressure it can deliver. (Just as you can squeeze a tangerine harder than you can squeeze a basketball.) So the more muscular the heart, the weaker the pumping. Worse, this effect can become a negative runaway -- the heart adds muscle to keep the pressure up -- which increases diameter, lowering pressure.</p><p></p><p>So you want to reverse significant enlargement if at all possible (successful reversal is called "reverse remodeling" of the ventricle.)</p><p></p><p>You will find no shortage of doctors, even cardiologists, who will tell you that LVH is irreversible, but the newest research is that adequate (high enough) doses of a newer beta blocker called carvedilol (Coreg) 2x/day can reverse much of it. </p><p></p><p>The reason carvedilol can do this where other beta blockers couldn't is coreg is one of the rare beta blockers that also reduces constriction in your veins and arteries. This reduces the 'back pressure' the heart contends with, so less force is needed to keep you oxygenated. So the ventricle is finally deloaded and the excess muscle mass can gradually revert toward normal. In some cases, almost complete reverse remodeling has been seen with similar restoration of ejection fraction.</p><p></p><p>Hit pubmed for endless cites, but here are a few good ones:</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484683/" target="_blank">25mg/day carvedilol reverses dilated cardiac myopathy</a></p><p></p><p><a href="https://medlineplus.gov/druginfo/meds/a697042.html" target="_blank">administration instructions</a></p><p><a href="http://www.rxlist.com/coreg-drug.htm" target="_blank">more info</a></p><p></p><p><a href="http://forum.lowcarber.org/showthread.php?p=7459351#post7459351" target="_blank">almost normal ejection fraction after 15 years at 50mg/day</a></p><p></p><p><a href="http://www.healthboards.com/boards/4643933-post11.html" target="_blank">another good result after 22 days at 50mg/day</a></p><p></p><p>Oh, one last thing -- carvedilol IMPROVES insulin resistance, whereas other beta blockers like metoprolol WORSEN it.</p><p></p><p>It's a pretty amazing drug.</p></blockquote><p></p>
[QUOTE="SoCal Guy, post: 59039, member: 14529"] The athletic version is not necessarily harmless. It depends on how over-size your ventricle actually is, not whether the cause was steroids or uncontrolled hypertension. The reason is basic physics -- the extra muscle actually [B]reduces [/B]ejection fraction, because the heart is a [B]round [/B]muscle. Therefore as the heart gets more muscular, its diameter increases -- which reduces the amount of pumping pressure it can deliver. (Just as you can squeeze a tangerine harder than you can squeeze a basketball.) So the more muscular the heart, the weaker the pumping. Worse, this effect can become a negative runaway -- the heart adds muscle to keep the pressure up -- which increases diameter, lowering pressure. So you want to reverse significant enlargement if at all possible (successful reversal is called "reverse remodeling" of the ventricle.) You will find no shortage of doctors, even cardiologists, who will tell you that LVH is irreversible, but the newest research is that adequate (high enough) doses of a newer beta blocker called carvedilol (Coreg) 2x/day can reverse much of it. The reason carvedilol can do this where other beta blockers couldn't is coreg is one of the rare beta blockers that also reduces constriction in your veins and arteries. This reduces the 'back pressure' the heart contends with, so less force is needed to keep you oxygenated. So the ventricle is finally deloaded and the excess muscle mass can gradually revert toward normal. In some cases, almost complete reverse remodeling has been seen with similar restoration of ejection fraction. Hit pubmed for endless cites, but here are a few good ones: [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484683/"]25mg/day carvedilol reverses dilated cardiac myopathy[/URL] [URL="https://medlineplus.gov/druginfo/meds/a697042.html"]administration instructions[/URL] [URL="http://www.rxlist.com/coreg-drug.htm"]more info[/URL] [URL="http://forum.lowcarber.org/showthread.php?p=7459351#post7459351"]almost normal ejection fraction after 15 years at 50mg/day[/URL] [URL="http://www.healthboards.com/boards/4643933-post11.html"]another good result after 22 days at 50mg/day[/URL] Oh, one last thing -- carvedilol IMPROVES insulin resistance, whereas other beta blockers like metoprolol WORSEN it. It's a pretty amazing drug. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Left Ventricle Hypertrophy and Nandrolone ( Decadurabolin )
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