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Metformin May Also Lower LDL Cholesterol: Study Suggests How

Metformin, which has been used to lower blood glucose levels in patients with type 2 diabetes for more than 50 years, appears to also lower LDL-cholesterol levels, possibly by a complex mechanism, according to new research.


In a study published online August 5 in Diabetes Care, Dr Tao Xu, from Helmholtz Zentrum Munchen, in Neuherberg, Germany, and colleagues describe how they analyzed levels of 131 serum metabolites as well as genomic data in three large cohorts of participants with treated or untreated type 2 diabetes, prediabetes, or no diabetes.


They found that patients who were taking metformin had lower levels of three metabolites and LDL cholesterol, senior author Dr Rui Wang-Sattler, from Helmholtz Zentrum Munchen and the German Center for Diabetes Research, told Medscape Medical News.


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