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Latest Update on Metformin
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<blockquote data-quote="Biobro" data-source="post: 241361" data-attributes="member: 43789"><p><h3>Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system</h3><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/26971375/[/URL]</p><p></p><p></p><h3></h3><h3></h3><h3></h3><h3>Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges</h3><p></p><h2>Conclusions</h2><p>Several works recently suggested that metformin may be used as a promising therapeutic strategy to counteract the progression of neurodegenerative disorders, including PD. However, despite intensive research, the precise mechanisms by which metformin exerts its activity are not completely understood. Therefore, to determine the potential therapeutic use of metformin as a disease modifier for PD, it is crucial to evaluate its main pharmacological properties, such as the bioavailability in the brain, the molecular pathways it affects, and the concentrations necessary to observe the beneficial effects. Unfortunately, the data available in the literature are often controversial and vary significantly among experimental models, prompting the necessity to outline a consensus in pre-clinical data interpretation.</p><p></p><p><strong>At the same time, the prolonged consumption of metformin at a relatively high dosage might induce serious side effects that could worsen the risk of developing PD over time. </strong>In this frame, the epidemiological studies that investigated the association between metformin therapy and PD only assessed the effect of the drug in T2DM patients [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B65-ijms-23-00398" target="_blank">65</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B66-ijms-23-00398" target="_blank">66</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B67-ijms-23-00398" target="_blank">67</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B68-ijms-23-00398" target="_blank">68</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B69-ijms-23-00398" target="_blank">69</a>].</p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/[/URL]</p><p></p><h3>Hypothesis: Metformin is a potential reproductive toxicant</h3><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/36339411/[/URL]</p><p></p><p></p><h3>Metformin Linked to More Severe Neuropathy Pain</h3><p>[URL unfurl="true"]https://www.diabetesselfmanagement.com/news-research/2021/03/12/metformin-linked-to-more-severe-neuropathy-pain/[/URL]</p></blockquote><p></p>
[QUOTE="Biobro, post: 241361, member: 43789"] [HEADING=2]Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system[/HEADING] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/26971375/[/URL] [HEADING=2][/HEADING] [HEADING=2][/HEADING] [HEADING=2][/HEADING] [HEADING=2]Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges[/HEADING] [HEADING=1]Conclusions[/HEADING] Several works recently suggested that metformin may be used as a promising therapeutic strategy to counteract the progression of neurodegenerative disorders, including PD. However, despite intensive research, the precise mechanisms by which metformin exerts its activity are not completely understood. Therefore, to determine the potential therapeutic use of metformin as a disease modifier for PD, it is crucial to evaluate its main pharmacological properties, such as the bioavailability in the brain, the molecular pathways it affects, and the concentrations necessary to observe the beneficial effects. Unfortunately, the data available in the literature are often controversial and vary significantly among experimental models, prompting the necessity to outline a consensus in pre-clinical data interpretation. [B]At the same time, the prolonged consumption of metformin at a relatively high dosage might induce serious side effects that could worsen the risk of developing PD over time. [/B]In this frame, the epidemiological studies that investigated the association between metformin therapy and PD only assessed the effect of the drug in T2DM patients [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B65-ijms-23-00398']65[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B66-ijms-23-00398']66[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B67-ijms-23-00398']67[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B68-ijms-23-00398']68[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/#B69-ijms-23-00398']69[/URL]]. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745385/[/URL] [HEADING=2]Hypothesis: Metformin is a potential reproductive toxicant[/HEADING] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/36339411/[/URL] [HEADING=2]Metformin Linked to More Severe Neuropathy Pain[/HEADING] [URL unfurl="true"]https://www.diabetesselfmanagement.com/news-research/2021/03/12/metformin-linked-to-more-severe-neuropathy-pain/[/URL] [/QUOTE]
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Latest Update on Metformin
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