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Health & Wellness
Latest Update on Metformin
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<blockquote data-quote="BigTex" data-source="post: 234687" data-attributes="member: 43589"><p>Not sure what kind she is taking but Metformin oral tablet comes in two forms: immediate-release and extended-release. Guys I know who have had stomach cramps etc say the extended release did not cause this. It might be for some the short release is much worse because of the speed it releases. I don't believe science has determined why Metformin causes gastrointestinal distress but there are different hypothesis proposed, including stimulation of intestinal secretion of serotonin, alteration in incretin and metabolism of glucose, and malabsorption of bile salts.</p><p></p><p>Some studies have shown taking metformin tablets at mealtimes, or using careful dose adjustment to minimize poor compliance with immediate release form of metformin or switching to extended release form of metformin can reduce GI symptoms. Another study show switching to capsules helped.</p><p></p><h3>Long-Term Metformin Use Linked with Vitamin B12 Deficiency</h3><p>[URL unfurl="true"]https://www.endocrineweb.com/news/diabetes/20265-long-term-metformin-use-linked-vitamin-b12-deficiency[/URL]</p></blockquote><p></p>
[QUOTE="BigTex, post: 234687, member: 43589"] Not sure what kind she is taking but Metformin oral tablet comes in two forms: immediate-release and extended-release. Guys I know who have had stomach cramps etc say the extended release did not cause this. It might be for some the short release is much worse because of the speed it releases. I don't believe science has determined why Metformin causes gastrointestinal distress but there are different hypothesis proposed, including stimulation of intestinal secretion of serotonin, alteration in incretin and metabolism of glucose, and malabsorption of bile salts. Some studies have shown taking metformin tablets at mealtimes, or using careful dose adjustment to minimize poor compliance with immediate release form of metformin or switching to extended release form of metformin can reduce GI symptoms. Another study show switching to capsules helped. [HEADING=2]Long-Term Metformin Use Linked with Vitamin B12 Deficiency[/HEADING] [URL unfurl="true"]https://www.endocrineweb.com/news/diabetes/20265-long-term-metformin-use-linked-vitamin-b12-deficiency[/URL] [/QUOTE]
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General Health & Fitness
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Latest Update on Metformin
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