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Latest Update on Metformin
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<blockquote data-quote="Nelson Vergel" data-source="post: 111861" data-attributes="member: 3"><p><strong>Love Affair With Metformin: Still Strong, or Time to Move On?</strong></p><p>.... "at $4 a month," it's hard to argue with the economics, she noted.</p><p></p><p>Newer drugs that have shown benefit in cardiovascular outcomes trials include the SGLT-2 inhibitors empagliflozin (Jardiance, Boehringer Ingelheim) in EMPA-REG OUTCOME and canagliflozin (Invokana, Johnson & Johnson) in CANVAS, and the GLP-1 agonists liraglutide (Victoza, Novo Nordisk) in LEADER and semaglutide (Ozempic, Novo Nordisk) in SUSTAIN-6.</p><p></p><p>But these studies were mainly conducted in patients with high-risk type 2 diabetes who had a long duration of disease and already had cardiovascular disease (CVD) or a number of risk factors for it.</p><p></p><p>"So these data do not directly translate to 87% of our population," requiring first-line therapy for type 2 diabetes, Aroda argued.</p><p></p><p>She also pointed to safety, acknowledging, "We all know the potential for gastrointestinal disturbances with metformin and B12 deficiency," but this pales in comparison to the numerous safety warnings issued for newer drugs over the past few years, she said."</p><p></p><p>..."metformin does not address many of the core pathophysiologies of type 2 diabetes, she argued, and secondly, "you do not improve metabolic parameters as well as other [drugs] can." Although metformin lowers HbA1c, it is fairly neutral when it comes to any benefits on weight, blood pressure, and lipids, for example."</p><p></p><p><a href="https://www.medscape.com/viewarticle/898478?src=WNL_confalert_180623_MSCPEDIT&uac=291811EY&impID=1666065&faf=1#vp_1" target="_blank">Source</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 111861, member: 3"] [b]Love Affair With Metformin: Still Strong, or Time to Move On?[/b] .... "at $4 a month," it's hard to argue with the economics, she noted. Newer drugs that have shown benefit in cardiovascular outcomes trials include the SGLT-2 inhibitors empagliflozin (Jardiance, Boehringer Ingelheim) in EMPA-REG OUTCOME and canagliflozin (Invokana, Johnson & Johnson) in CANVAS, and the GLP-1 agonists liraglutide (Victoza, Novo Nordisk) in LEADER and semaglutide (Ozempic, Novo Nordisk) in SUSTAIN-6. But these studies were mainly conducted in patients with high-risk type 2 diabetes who had a long duration of disease and already had cardiovascular disease (CVD) or a number of risk factors for it. "So these data do not directly translate to 87% of our population," requiring first-line therapy for type 2 diabetes, Aroda argued. She also pointed to safety, acknowledging, "We all know the potential for gastrointestinal disturbances with metformin and B12 deficiency," but this pales in comparison to the numerous safety warnings issued for newer drugs over the past few years, she said." ..."metformin does not address many of the core pathophysiologies of type 2 diabetes, she argued, and secondly, "you do not improve metabolic parameters as well as other [drugs] can." Although metformin lowers HbA1c, it is fairly neutral when it comes to any benefits on weight, blood pressure, and lipids, for example." [URL="https://www.medscape.com/viewarticle/898478?src=WNL_confalert_180623_MSCPEDIT&uac=291811EY&impID=1666065&faf=1#vp_1"]Source[/URL] [/QUOTE]
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Latest Update on Metformin
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