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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Labs after switching to EOD schedule
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<blockquote data-quote="madman" data-source="post: 160634" data-attributes="member: 13851"><p>Just so you understand the newer references ranges for TT let alone FT (TruT calculated method) are based off of more recent studies using more accurate assays.</p><p></p><p></p><p></p><p></p><p>Regarding Total Testosterone:</p><p></p><p><span style="font-size: 26px"><strong>Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe</strong></span></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460736/" target="_blank">Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe</a></p><p></p><p></p><p><span style="font-size: 18px"><strong>Results:</strong></span></p><p>Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages. <strong><span style="color: rgb(184, 49, 47)">In healthy nonobese men, 19 to 39 years, </span>harmonized 2.5th, 5th, 50th, 95th, and 97.5th percentile values were 264, 303, 531, 852, and 916 ng/dL, respectively. </strong>Age-specific harmonized testosterone concentrations in nonobese men were similar across cohorts and greater than in all men.</p><p></p><p><span style="font-size: 18px"><strong>Conclusion:</strong></span></p><p><strong>Harmonized normal range in a <span style="color: rgb(184, 49, 47)">healthy nonobese</span> population of European and American men, 19 to 39 years, <span style="color: rgb(184, 49, 47)">is 264 to 916 ng/dL.</span></strong> A substantial proportion of intercohort variation in testosterone levels is due to assay differences. These data demonstrate the feasibility of generating harmonized reference ranges for testosterone that can be applied to assays, which have been calibrated to a reference method and calibrator</p><p></p><p></p><p></p><p>Regarding Free Testosterone using the newer calculated TruT model/algorithm:</p><p></p><p><strong>"<span style="color: rgb(44, 130, 201)">Based on the new data on the distribution of free testosterone levels in</span><span style="color: rgb(184, 49, 47)"> healthy men</span> the target range of free testosterone has been determined to be <span style="color: rgb(184, 49, 47)">164 to 314 pg/ml (mean+/−1SD)</span>"</strong></p><p></p><p></p><p>Which would convert to <strong><span style="color: rgb(184, 49, 47)">16-31 ng/dl</span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>Now do understand that on trt we use these ranges as guidelines.....it is in no way set in stone that one needs to stay within such ranges.</p><p></p><p>Some may choose/need to run slightly higher TT/FT levels when on trt and as long as blood markers are healthy and one feels well overall so be it.</p><p></p><p>As we know symptom relief is what truly matters not numbers but again even than we most likely do not need to achieve/run absurd TT/FT levels to benefit from testosterone replacement!</p><p></p><p>Do what is best for you within being sensible regarding your overall health.</p></blockquote><p></p>
[QUOTE="madman, post: 160634, member: 13851"] Just so you understand the newer references ranges for TT let alone FT (TruT calculated method) are based off of more recent studies using more accurate assays. Regarding Total Testosterone: [SIZE=26px][B]Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe[/B][/SIZE] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460736/']Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe[/URL] [SIZE=18px][B]Results:[/B][/SIZE] Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages. [B][COLOR=rgb(184, 49, 47)]In healthy nonobese men, 19 to 39 years, [/COLOR]harmonized 2.5th, 5th, 50th, 95th, and 97.5th percentile values were 264, 303, 531, 852, and 916 ng/dL, respectively. [/B]Age-specific harmonized testosterone concentrations in nonobese men were similar across cohorts and greater than in all men. [SIZE=18px][B]Conclusion:[/B][/SIZE] [B]Harmonized normal range in a [COLOR=rgb(184, 49, 47)]healthy nonobese[/COLOR] population of European and American men, 19 to 39 years, [COLOR=rgb(184, 49, 47)]is 264 to 916 ng/dL.[/COLOR][/B] A substantial proportion of intercohort variation in testosterone levels is due to assay differences. These data demonstrate the feasibility of generating harmonized reference ranges for testosterone that can be applied to assays, which have been calibrated to a reference method and calibrator Regarding Free Testosterone using the newer calculated TruT model/algorithm: [B]"[COLOR=rgb(44, 130, 201)]Based on the new data on the distribution of free testosterone levels in[/COLOR][COLOR=rgb(184, 49, 47)] healthy men[/COLOR] the target range of free testosterone has been determined to be [COLOR=rgb(184, 49, 47)]164 to 314 pg/ml (mean+/−1SD)[/COLOR]"[/B] Which would convert to [B][COLOR=rgb(184, 49, 47)]16-31 ng/dl[/COLOR][/B] Now do understand that on trt we use these ranges as guidelines.....it is in no way set in stone that one needs to stay within such ranges. Some may choose/need to run slightly higher TT/FT levels when on trt and as long as blood markers are healthy and one feels well overall so be it. As we know symptom relief is what truly matters not numbers but again even than we most likely do not need to achieve/run absurd TT/FT levels to benefit from testosterone replacement! Do what is best for you within being sensible regarding your overall health. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Labs after switching to EOD schedule
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