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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
LabCorp vs Quest Total T: Why the Discrepancy?
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<blockquote data-quote="jcmaxwell" data-source="post: 181351" data-attributes="member: 38456"><p>I have been following the same protocol for the last 12 months: 70 mg Test Cypionate twice weekly; 500 IU hCG twice weekly; 0.1 mg Anastrozole daily. I run blood tests just prior to the next injection cycle.</p><p></p><p><strong>TOTAL TESTOSTERONE</strong></p><p></p><p>1204 ng/dL LabCorp (Immunoassay 264-916) April 24</p><p></p><p>1891 ng/dL Quest (LC/MS/MS 250-1100) June 25</p><p></p><p><strong>FREE TESTOSTERONE </strong></p><p></p><p>>50 pg/mL LabCorp (Direct Immunoassay 6.6-18.1) April 24</p><p></p><p>548.2 pg/mL Quest (Dialysis) 35-155) June 25</p><p></p><p><strong>E2, SENSITIVE</strong></p><p></p><p>29.7 pg/mL LabCorp (LC/MS/MS 8-35) April 24</p><p></p><p>67 pg/mL Quest (LC/MS/MS) June 25</p><p></p><p>I fully understand that there is no correlation between free Testosterone Direct and free Testosterone by Dialysis, as they have completely different reference ranges. In fact, Direct Immunoassay fT has been completed discredited over the last 20 years. William Rosner wrote a scathing Letter to the Editor (July 2001, Journal of Endocrinology and Metabolism) entitled, “An Extraordinarily Inaccurate Assay for Free Testosterone is Still with Us”. He cited the work of Vermeulen and others demonstrating that Direct Immunoassay fT “is seriously inaccurate, underestimating its concentration by many-fold”.</p><p></p><p>But I do not understand why there is such a big difference between LabCorp’s and Quest’s Total Testosterone. Perhaps Nelson can offer his words of wisdom.</p></blockquote><p></p>
[QUOTE="jcmaxwell, post: 181351, member: 38456"] I have been following the same protocol for the last 12 months: 70 mg Test Cypionate twice weekly; 500 IU hCG twice weekly; 0.1 mg Anastrozole daily. I run blood tests just prior to the next injection cycle. [B]TOTAL TESTOSTERONE[/B] 1204 ng/dL LabCorp (Immunoassay 264-916) April 24 1891 ng/dL Quest (LC/MS/MS 250-1100) June 25 [B]FREE TESTOSTERONE [/B] >50 pg/mL LabCorp (Direct Immunoassay 6.6-18.1) April 24 548.2 pg/mL Quest (Dialysis) 35-155) June 25 [B]E2, SENSITIVE[/B] 29.7 pg/mL LabCorp (LC/MS/MS 8-35) April 24 67 pg/mL Quest (LC/MS/MS) June 25 I fully understand that there is no correlation between free Testosterone Direct and free Testosterone by Dialysis, as they have completely different reference ranges. In fact, Direct Immunoassay fT has been completed discredited over the last 20 years. William Rosner wrote a scathing Letter to the Editor (July 2001, Journal of Endocrinology and Metabolism) entitled, “An Extraordinarily Inaccurate Assay for Free Testosterone is Still with Us”. He cited the work of Vermeulen and others demonstrating that Direct Immunoassay fT “is seriously inaccurate, underestimating its concentration by many-fold”. But I do not understand why there is such a big difference between LabCorp’s and Quest’s Total Testosterone. Perhaps Nelson can offer his words of wisdom. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
LabCorp vs Quest Total T: Why the Discrepancy?
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