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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Lab Work - What to Track in the Future?
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<blockquote data-quote="madman" data-source="post: 143805" data-attributes="member: 13851"><p><h3>Population Pharmacokinetic/Pharmacodynamic Modeling of Depot Testosterone Cypionate in Healthy Male Subjects (2018)</h3><p></p><p><strong><em><u>It is difficult to calculate the PK parameters of TC using traditional noncompartmental methods</u>, especially when the endogenous testosterone secretion rate is suppressed during the course of TC administration and the testosterone secretion rate is regulated by the LH‐testosterone feedback loop system in the HPG axis. </em><u>Our estimated <em>post hoc</em> median tT half‐life was 4.05 days</u>, <span style="color: rgb(184, 49, 47)"><u>which is shorter than the mean reported elimination half‐life of 6.9 days determined using noncompartmental analysis</u>.</span></strong><span style="color: rgb(184, 49, 47)"><a href="https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12287#psp412287-bib-0011" target="_blank"><strong>11</strong></a></span> <strong><em>Such inconsistency is believed to result from failure to consider endogenous testosterone production.</em></strong> <strong>When <span style="color: rgb(184, 49, 47)">we assume </span>endogenous testosterone secretion is 0 in the PPK analysis, the median estimated half‐life increases to <span style="color: rgb(184, 49, 47)">6.87 days. </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 143805, member: 13851"] [HEADING=2]Population Pharmacokinetic/Pharmacodynamic Modeling of Depot Testosterone Cypionate in Healthy Male Subjects (2018)[/HEADING] [B][I][U]It is difficult to calculate the PK parameters of TC using traditional noncompartmental methods[/U], especially when the endogenous testosterone secretion rate is suppressed during the course of TC administration and the testosterone secretion rate is regulated by the LH‐testosterone feedback loop system in the HPG axis. [/I][U]Our estimated [I]post hoc[/I] median tT half‐life was 4.05 days[/U], [COLOR=rgb(184, 49, 47)][U]which is shorter than the mean reported elimination half‐life of 6.9 days determined using noncompartmental analysis[/U].[/COLOR][/B][COLOR=rgb(184, 49, 47)][URL='https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12287#psp412287-bib-0011'][B]11[/B][/URL][/COLOR] [B][I]Such inconsistency is believed to result from failure to consider endogenous testosterone production.[/I][/B] [B]When [COLOR=rgb(184, 49, 47)]we assume [/COLOR]endogenous testosterone secretion is 0 in the PPK analysis, the median estimated half‐life increases to [COLOR=rgb(184, 49, 47)]6.87 days. [/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Lab Work - What to Track in the Future?
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