ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Nutrition and Supplements
L-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 181033" data-attributes="member: 13851"><p>[ATTACH=full]9935[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 1.</span><span style="color: rgb(44, 130, 201)"> Potential mechanisms by which aging impairs vascular function</span> </strong></p><p><strong><span style="color: rgb(44, 130, 201)">(A) </span>and<span style="color: rgb(184, 49, 47)"> oral L-CIT may improve age-related vascular dysfunction</span> <span style="color: rgb(184, 49, 47)">(B)</span>. L-ARG is catabolized by the enzyme arginase into urea and L-ornithine <span style="color: rgb(44, 130, 201)">(1)</span>. Age-related increased NADPH oxidase (NOx) activity increases superoxide anion (O2 −) production <span style="color: rgb(44, 130, 201)">(2) </span>and contributes to decrease BH4, leading to eNOS uncoupling <span style="color: rgb(44, 130, 201)">(3)</span>. Uncoupled eNOS produces O2 −, which reacts with NO to produce peroxynitrite (ONOO−) <span style="color: rgb(44, 130, 201)">(3)</span>, a substance that causes oxidative cell damage. The resultant low NO fails to properly activate the guanylate cyclase (GC)–GTP–cGMP signal transduction pathway, leading to impaired vasodilation<span style="color: rgb(44, 130, 201)"> (4)</span>. L-Ornithine produced by arginase increases the production of polyamine and proline, resulting in collagen synthesis and cell proliferation contributing to arterial stiffness <span style="color: rgb(44, 130, 201)">(5)</span>. Oral L-CIT supplementation increases L-ARG bioavailability for eNOS by greater de novo synthesis <span style="color: rgb(184, 49, 47)">(6)</span> and inhibition of arginase activity <span style="color: rgb(184, 49, 47)">(7)</span>, resulting in improved NO-mediated vasodilation <span style="color: rgb(184, 49, 47)">(8)</span> and decreased arterial stiffness <span style="color: rgb(184, 49, 47)">(9)</span>. <span style="color: rgb(184, 49, 47)">The precise mechanism by which L-CIT may decrease arterial stiffness is yet unknown. </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 181033, member: 13851"] [ATTACH type="full" alt="Screenshot (1532).png"]9935[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 1.[/COLOR][COLOR=rgb(44, 130, 201)] Potential mechanisms by which aging impairs vascular function[/COLOR] [COLOR=rgb(44, 130, 201)](A) [/COLOR]and[COLOR=rgb(184, 49, 47)] oral L-CIT may improve age-related vascular dysfunction[/COLOR] [COLOR=rgb(184, 49, 47)](B)[/COLOR]. L-ARG is catabolized by the enzyme arginase into urea and L-ornithine [COLOR=rgb(44, 130, 201)](1)[/COLOR]. Age-related increased NADPH oxidase (NOx) activity increases superoxide anion (O2 −) production [COLOR=rgb(44, 130, 201)](2) [/COLOR]and contributes to decrease BH4, leading to eNOS uncoupling [COLOR=rgb(44, 130, 201)](3)[/COLOR]. Uncoupled eNOS produces O2 −, which reacts with NO to produce peroxynitrite (ONOO−) [COLOR=rgb(44, 130, 201)](3)[/COLOR], a substance that causes oxidative cell damage. The resultant low NO fails to properly activate the guanylate cyclase (GC)–GTP–cGMP signal transduction pathway, leading to impaired vasodilation[COLOR=rgb(44, 130, 201)] (4)[/COLOR]. L-Ornithine produced by arginase increases the production of polyamine and proline, resulting in collagen synthesis and cell proliferation contributing to arterial stiffness [COLOR=rgb(44, 130, 201)](5)[/COLOR]. Oral L-CIT supplementation increases L-ARG bioavailability for eNOS by greater de novo synthesis [COLOR=rgb(184, 49, 47)](6)[/COLOR] and inhibition of arginase activity [COLOR=rgb(184, 49, 47)](7)[/COLOR], resulting in improved NO-mediated vasodilation [COLOR=rgb(184, 49, 47)](8)[/COLOR] and decreased arterial stiffness [COLOR=rgb(184, 49, 47)](9)[/COLOR]. [COLOR=rgb(184, 49, 47)]The precise mechanism by which L-CIT may decrease arterial stiffness is yet unknown. [/COLOR][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Nutrition and Supplements
L-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top