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General Health & Fitness
Nutrition and Supplements
L-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
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<blockquote data-quote="madman" data-source="post: 181032" data-attributes="member: 13851"><p><span style="color: rgb(184, 49, 47)"><em>Age-associated reduction in endothelial nitric oxide (NO) synthesis contributes to the development of cardiovascular diseases and sarcopenia. L-Citrulline is a precursor of NO with the ability to improve vascular function and muscle protein synthesis.</em></span><span style="color: rgb(44, 130, 201)"><em> We hypothesize that the vascular and muscular benefits associated with oral L-citrulline supplementation might be augmented by concomitant supplementation with exercise training in older adults.</em></span></p><p></p><p></p><p></p><p></p><p><strong>Key Points</strong></p><p></p><p><em>• <span style="color: rgb(184, 49, 47)">Aging is associated with hypertension and reduced muscle mass and strength (quality) that may be mediated by impaired nitric oxide bioavailability. </span></em></p><p><em></em></p><p><em>•<span style="color: rgb(184, 49, 47)"> Oral L-citrulline increases plasma L-arginine and nitric oxide production. </span></em></p><p><em></em></p><p><em>•<span style="color: rgb(184, 49, 47)"> L-Citrulline supplementation improves muscle protein synthesis, muscle mass, and oxygen delivery that may benefit exercise performance. </span></em></p><p><em></em></p><p><em>• </em><span style="color: rgb(184, 49, 47)"><em>Combined with exercise training, L-citrulline may benefit vascular and muscular function via improvements in nitric oxide bioavailability and muscle protein synthesis in older adults. </em></span></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>SUMMARY</strong></span></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong><em>Evidence continues to emerge on the positive impact of chronic L-CIT on vascular and skeletal muscle function in older adults. L-CIT may improve exercise capacity by upregulating muscular perfusion and subsequent oxygen utilization. Evidence suggests that increased L-ARG and NO availability in skeletal muscle may be a crucial factor in promoting muscle function via PGC-1α stimulation of mitochondrial respiratory capacity. In addition, the action of L-CIT on muscle function also is related to its ability to promote muscle protein synthesis. </em></strong></span><em><span style="color: rgb(0, 0, 0)">Indeed, there are many studies that establish a continuum between experimental and clinical research that confirms its action. Although animal research is revealing mechanistic insight into how L-CIT positively alters the regulation of these physiological systems, human research is highlighting the effect of L-CIT on exercise performance and adaptations with exercise training. </span></em><span style="color: rgb(44, 130, 201)"><em><strong>Future research is still needed to decipher the contribution of endothelial versus neuronal NO production to the vascular and muscular benefits observed after L-CIT supplementation to fully understand the ergogenic and therapeutic potential of this amino acid. </strong></em><strong><em>More studies will be needed to investigate the additive clinical benefits of L-CIT supplementation and exercise training on arterial and muscle functions in older adults.</em></strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 181032, member: 13851"] [COLOR=rgb(184, 49, 47)][I]Age-associated reduction in endothelial nitric oxide (NO) synthesis contributes to the development of cardiovascular diseases and sarcopenia. L-Citrulline is a precursor of NO with the ability to improve vascular function and muscle protein synthesis.[/I][/COLOR][COLOR=rgb(44, 130, 201)][I] We hypothesize that the vascular and muscular benefits associated with oral L-citrulline supplementation might be augmented by concomitant supplementation with exercise training in older adults.[/I][/COLOR] [B]Key Points[/B] [I]• [COLOR=rgb(184, 49, 47)]Aging is associated with hypertension and reduced muscle mass and strength (quality) that may be mediated by impaired nitric oxide bioavailability. [/COLOR] •[COLOR=rgb(184, 49, 47)] Oral L-citrulline increases plasma L-arginine and nitric oxide production. [/COLOR] •[COLOR=rgb(184, 49, 47)] L-Citrulline supplementation improves muscle protein synthesis, muscle mass, and oxygen delivery that may benefit exercise performance. [/COLOR] • [/I][COLOR=rgb(184, 49, 47)][I]Combined with exercise training, L-citrulline may benefit vascular and muscular function via improvements in nitric oxide bioavailability and muscle protein synthesis in older adults. [/I][/COLOR] [COLOR=rgb(0, 0, 0)][B]SUMMARY[/B][/COLOR] [COLOR=rgb(184, 49, 47)][B][I]Evidence continues to emerge on the positive impact of chronic L-CIT on vascular and skeletal muscle function in older adults. L-CIT may improve exercise capacity by upregulating muscular perfusion and subsequent oxygen utilization. Evidence suggests that increased L-ARG and NO availability in skeletal muscle may be a crucial factor in promoting muscle function via PGC-1α stimulation of mitochondrial respiratory capacity. In addition, the action of L-CIT on muscle function also is related to its ability to promote muscle protein synthesis. [/I][/B][/COLOR][I][COLOR=rgb(0, 0, 0)]Indeed, there are many studies that establish a continuum between experimental and clinical research that confirms its action. Although animal research is revealing mechanistic insight into how L-CIT positively alters the regulation of these physiological systems, human research is highlighting the effect of L-CIT on exercise performance and adaptations with exercise training. [/COLOR][/I][COLOR=rgb(44, 130, 201)][I][B]Future research is still needed to decipher the contribution of endothelial versus neuronal NO production to the vascular and muscular benefits observed after L-CIT supplementation to fully understand the ergogenic and therapeutic potential of this amino acid. [/B][/I][B][I]More studies will be needed to investigate the additive clinical benefits of L-CIT supplementation and exercise training on arterial and muscle functions in older adults.[/I][/B][/COLOR] [/QUOTE]
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General Health & Fitness
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L-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
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