ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Kisspeptin-10 as a replacement for compounded HCG?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 172983" data-attributes="member: 38109"><p>The explanation of its function doesn't match what <a href="https://en.wikipedia.org/wiki/Kisspeptin" target="_blank">Wiki says</a>:</p><p></p><p style="margin-left: 20px"><em>Kisspeptin's ability to stimulate the release of GnRH and <a href="https://en.wikipedia.org/wiki/Gonadotropins" target="_blank">gonadotropins</a> is the result of its effect on GnRH release at the <a href="https://en.wikipedia.org/wiki/Hypothalamus" target="_blank">hypothalamus</a>.</em></p> <p style="margin-left: 20px"></p><p>What I was wondering is whether or not you need pulsatile delivery of kisspeptin to get normal pulsatile release of GnRH. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902960/" target="_blank">This research</a> says it's not necessary.</p><p></p><p style="margin-left: 20px"><em>The ability of continuous kisspeptin infusion to induce pulsatile gonadotropin secretion further indicates that GnRH neurons are able to set up pulsatile secretion in the absence of pulsatile exogenous kisspeptin.</em></p><p></p><p>Because most men with non-primary hypogonadism respond to clomiphene to some degree it seems as though pituitary reception is not the issue and kisspeptin is an interesting avenue of treatment. However, there is definitely negative feedback from estrogens at the pituitary, and possibly also some from androgens, so the use of kisspeptin with TRT is problematic, and may at a minimum require the use of a SERM.</p><p></p><p>Another potential issue is half-life. Assuming oral delivery isn't possible, the iv infusion half-life is <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232613/" target="_blank">four minutes</a>, so even if the half-life for subcutaneous administration is ten times as long then you are still looking at a pretty short duration of action. Is the doctor proposing an infusion pump or multiple daily injections?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 172983, member: 38109"] The explanation of its function doesn't match what [URL='https://en.wikipedia.org/wiki/Kisspeptin']Wiki says[/URL]: [INDENT][I]Kisspeptin's ability to stimulate the release of GnRH and [URL='https://en.wikipedia.org/wiki/Gonadotropins']gonadotropins[/URL] is the result of its effect on GnRH release at the [URL='https://en.wikipedia.org/wiki/Hypothalamus']hypothalamus[/URL].[/I][/INDENT] [INDENT][/INDENT] What I was wondering is whether or not you need pulsatile delivery of kisspeptin to get normal pulsatile release of GnRH. [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902960/']This research[/URL] says it's not necessary. [INDENT][I]The ability of continuous kisspeptin infusion to induce pulsatile gonadotropin secretion further indicates that GnRH neurons are able to set up pulsatile secretion in the absence of pulsatile exogenous kisspeptin.[/I][/INDENT] Because most men with non-primary hypogonadism respond to clomiphene to some degree it seems as though pituitary reception is not the issue and kisspeptin is an interesting avenue of treatment. However, there is definitely negative feedback from estrogens at the pituitary, and possibly also some from androgens, so the use of kisspeptin with TRT is problematic, and may at a minimum require the use of a SERM. Another potential issue is half-life. Assuming oral delivery isn't possible, the iv infusion half-life is [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232613/']four minutes[/URL], so even if the half-life for subcutaneous administration is ten times as long then you are still looking at a pretty short duration of action. Is the doctor proposing an infusion pump or multiple daily injections? [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Kisspeptin-10 as a replacement for compounded HCG?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top