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Mental Health
Ketamine: A tale of two enantiomers
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<blockquote data-quote="madman" data-source="post: 198084" data-attributes="member: 13851"><p><strong><em>*The discovery of the rapid antidepressant effects of (R,S)- ketamine, including in treatment-resistant patients, has appropriately been hailed ‘the most important discovery in half a century in depression research (Duman and Aghajanian, 2012). Through the drug development and clinical trials process, the (S)-ketamine nasal spray, SpravatoTM, has been approved in both the United States and Europe, although some concerns remain regarding the efficacy and side effects.</em></strong></p><p></p><p>[URL unfurl="true"]https://www.spravato.com/[/URL]</p><p>[ATTACH=full]13471[/ATTACH]</p><p>[ATTACH=full]13472[/ATTACH]</p><p></p><p><strong>What is SPRAVATO® (esketamine) CIII nasal spray?</strong></p><p><strong>SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat:</strong></p><ul> <li data-xf-list-type="ul"> Adults with treatment-resistant depression (TRD)</li> <li data-xf-list-type="ul"> Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions</li> </ul><p>SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.</p><p>It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if the improvement is experienced after the first dose of SPRAVATO®.</p><p>It is not known if SPRAVATO® is safe and effective in children.</p></blockquote><p></p>
[QUOTE="madman, post: 198084, member: 13851"] [B][I]*The discovery of the rapid antidepressant effects of (R,S)- ketamine, including in treatment-resistant patients, has appropriately been hailed ‘the most important discovery in half a century in depression research (Duman and Aghajanian, 2012). Through the drug development and clinical trials process, the (S)-ketamine nasal spray, SpravatoTM, has been approved in both the United States and Europe, although some concerns remain regarding the efficacy and side effects.[/I][/B] [URL unfurl="true"]https://www.spravato.com/[/URL] [ATTACH type="full"]13471[/ATTACH] [ATTACH type="full"]13472[/ATTACH] [B]What is SPRAVATO® (esketamine) CIII nasal spray? SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat:[/B] [LIST] [*] Adults with treatment-resistant depression (TRD) [*] Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions [/LIST] SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine. It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if the improvement is experienced after the first dose of SPRAVATO®. It is not known if SPRAVATO® is safe and effective in children. [/QUOTE]
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Mental Health
Ketamine: A tale of two enantiomers
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