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Mental Health
Ketamine: A tale of two enantiomers
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<blockquote data-quote="madman" data-source="post: 198080" data-attributes="member: 13851"><p><strong>Figure 2. Major metabolites of (S)-ketamine and (R)-ketamine. (S)-ketamine or (R)-ketamine are initially metabolized to (S)-norketamine or (R)- norketamine via CYP3A4 or CYP2B6. (S)-norketamine or (R)-norketamine are further metabolized to (S)-dehydronorketamine (DHNK) or (R)-DHNK. (S)-norketamine or (R)-norketamine is metabolized to (2S,6S)-hydroxynorketamine (HNK) or (2R,6R)-HNK via CYP2A6. (S)-ketamine or (R)- ketamine may also be metabolized to (2S,6S)-HK or (2R,6R)-hydroxyketamine (HK) via CYP2A6 before transformation to (2S,6S)-HNK or (2R,6R)- HNK. Metabolites identified as candidate antidepressants are highlighted in dashed boxes.</strong></p><p><strong>[ATTACH=full]13465[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 198080, member: 13851"] [B]Figure 2. Major metabolites of (S)-ketamine and (R)-ketamine. (S)-ketamine or (R)-ketamine are initially metabolized to (S)-norketamine or (R)- norketamine via CYP3A4 or CYP2B6. (S)-norketamine or (R)-norketamine are further metabolized to (S)-dehydronorketamine (DHNK) or (R)-DHNK. (S)-norketamine or (R)-norketamine is metabolized to (2S,6S)-hydroxynorketamine (HNK) or (2R,6R)-HNK via CYP2A6. (S)-ketamine or (R)- ketamine may also be metabolized to (2S,6S)-HK or (2R,6R)-hydroxyketamine (HK) via CYP2A6 before transformation to (2S,6S)-HNK or (2R,6R)- HNK. Metabolites identified as candidate antidepressants are highlighted in dashed boxes. [ATTACH type="full"]13465[/ATTACH][/B] [/QUOTE]
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Mental Health
Ketamine: A tale of two enantiomers
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