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Just Started TrT and am Very Confused
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<blockquote data-quote="Cataceous" data-source="post: 264720" data-attributes="member: 38109"><p>Unfortunately topical testosterone doesn't qualify as fast-acting with respect to the HPTA. The skin acts as a reservoir and ensures a relatively long half-life. Instead we have testosterone nasal gel or troches delivered bucally. There is direct research showing that the HPTA continues to function when Natesto is used. Buccal troches provide similar pharmacokinetics, so it's inferred that results should be similar if the amount of testosterone absorbed is similar.</p><p></p><p>I think fast-acting testosterone is a better starting point than Clomid or enclomiphene. These latter drugs work for some men, but they introduce complexity and sometimes do as much harm as good. Clomid may be thought of as a mixture of enclomiphene and a long-acting estrogen (zuclomiphene). If the anti-estrogenic activity of enclomiphene happens to properly balance against the pro-estrogenic activity of zuclomiphene — and the added HPTA activity — then there may be decent results. If not, well some guys report feeling awful on Clomid. With enclomiphene alone it's hypothesized that there's insufficient estrogenic activity in certain regions of the brain in some cases, leading to poor subjective outcomes even when lab work looks fine.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 264720, member: 38109"] Unfortunately topical testosterone doesn't qualify as fast-acting with respect to the HPTA. The skin acts as a reservoir and ensures a relatively long half-life. Instead we have testosterone nasal gel or troches delivered bucally. There is direct research showing that the HPTA continues to function when Natesto is used. Buccal troches provide similar pharmacokinetics, so it's inferred that results should be similar if the amount of testosterone absorbed is similar. I think fast-acting testosterone is a better starting point than Clomid or enclomiphene. These latter drugs work for some men, but they introduce complexity and sometimes do as much harm as good. Clomid may be thought of as a mixture of enclomiphene and a long-acting estrogen (zuclomiphene). If the anti-estrogenic activity of enclomiphene happens to properly balance against the pro-estrogenic activity of zuclomiphene — and the added HPTA activity — then there may be decent results. If not, well some guys report feeling awful on Clomid. With enclomiphene alone it's hypothesized that there's insufficient estrogenic activity in certain regions of the brain in some cases, leading to poor subjective outcomes even when lab work looks fine. [/QUOTE]
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Just Started TrT and am Very Confused
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