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Me too, I feel very emotional, depressed and anxious lately. Also notice hot flashes. I open the window because Im so hot then in 20 minutes I close it and up the heat. A lot of anxiety and trouble sleeping. Also very itchy right nipple. I have had to start taking Xanax to relax. All this started recently when I added HCG to the 80mg of weekly T. My E2 prior was 45. I will be getting a blood test next week to see where Im at. I suspect it's high.