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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Jatenzo, an Oral Testosterone Replacement Therapy
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<blockquote data-quote="madman" data-source="post: 171520" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">12.3</span> Pharmacokinetics </strong></p><p></p><p><strong>Absorption </strong></p><p></p><p><span style="color: rgb(184, 49, 47)">JATENZO</span> delivers physiologic amounts of testosterone, producing testosterone concentrations that approximate normal concentrations seen in healthy men.</p><p></p><p><span style="color: rgb(184, 49, 47)">JATENZO</span> was taken orally at a starting dose of 237 mg twice per day with meals in a multicenter, open-label, randomized, 2-arm, active-controlled trial in hypogonadal males. The dose was adjusted, as needed, on Days 14 and 56 between a minimum of 158 mg twice per day and a maximum of 396 mg twice per day based on the average plasma testosterone concentration obtained over 24 hours after the morning dose. The average daily NaF-EDTA plasma testosterone concentration was 403 (± 128) ng/dL at the end of treatment, where the normal eugonadal range in NaF-EDTA plasma was 252-907 ng/dL in this study. Note that the titration scheme for use in clinical practice is based on serum total testosterone [see Dosage and Administration (2.2)].</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Table 3 </span></strong>summarizes the pharmacokinetic (PK) parameters for plasma total testosterone in patients completing at least 105 days of <span style="color: rgb(184, 49, 47)">JATENZO </span>treatment administered twice daily.</p><p>[ATTACH=full]9215[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 171520, member: 13851"] [B][COLOR=rgb(184, 49, 47)]12.3[/COLOR] Pharmacokinetics [/B] [B]Absorption [/B] [COLOR=rgb(184, 49, 47)]JATENZO[/COLOR] delivers physiologic amounts of testosterone, producing testosterone concentrations that approximate normal concentrations seen in healthy men. [COLOR=rgb(184, 49, 47)]JATENZO[/COLOR] was taken orally at a starting dose of 237 mg twice per day with meals in a multicenter, open-label, randomized, 2-arm, active-controlled trial in hypogonadal males. The dose was adjusted, as needed, on Days 14 and 56 between a minimum of 158 mg twice per day and a maximum of 396 mg twice per day based on the average plasma testosterone concentration obtained over 24 hours after the morning dose. The average daily NaF-EDTA plasma testosterone concentration was 403 (± 128) ng/dL at the end of treatment, where the normal eugonadal range in NaF-EDTA plasma was 252-907 ng/dL in this study. Note that the titration scheme for use in clinical practice is based on serum total testosterone [see Dosage and Administration (2.2)]. [B][COLOR=rgb(184, 49, 47)]Table 3 [/COLOR][/B]summarizes the pharmacokinetic (PK) parameters for plasma total testosterone in patients completing at least 105 days of [COLOR=rgb(184, 49, 47)]JATENZO [/COLOR]treatment administered twice daily. [ATTACH=full]9215[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Jatenzo, an Oral Testosterone Replacement Therapy
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