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Testosterone Replacement, Low T, HCG, & Beyond
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Issues with Empower Test-CYP?
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<blockquote data-quote="Cataceous" data-source="post: 274142" data-attributes="member: 38109"><p>To perform this evaluation properly it's essential to measure free testosterone; total testosterone can vary if SHBG changes, whereas free testosterone is expected to remain proportional to dose. Free testosterone must be measured with an accurate method, such as equilibrium dialysis — immunoassay-based tests, sometimes called "direct", are useless. Alternatively, free testosterone can be estimated with the Vermeulen calculation, which requires measuring total testosterone, SHBG, and ideally albumin as well.</p><p></p><p>It's also important to test at the same time in the injection cycle. However — assuming we're talking about a longer ester like cypionate — if the inter-injection interval is greater than a day or two then one should be aware that changes in the absorption rate can skew the results. This can be caused by various factors, including varying activity level and injection site. One should also inspect the injection site each time to ensure there has been no leakage.</p><p></p><p>The fairest comparison would be done with daily injections and after a significant stabilization period. You can see that it's not exactly trivial to minimize all of the possible confounding variables. It might be easier — and more accurate — to send the product out to a lab for testing. Aren't compounding pharmacies required to perform such testing anyway?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 274142, member: 38109"] To perform this evaluation properly it's essential to measure free testosterone; total testosterone can vary if SHBG changes, whereas free testosterone is expected to remain proportional to dose. Free testosterone must be measured with an accurate method, such as equilibrium dialysis — immunoassay-based tests, sometimes called "direct", are useless. Alternatively, free testosterone can be estimated with the Vermeulen calculation, which requires measuring total testosterone, SHBG, and ideally albumin as well. It's also important to test at the same time in the injection cycle. However — assuming we're talking about a longer ester like cypionate — if the inter-injection interval is greater than a day or two then one should be aware that changes in the absorption rate can skew the results. This can be caused by various factors, including varying activity level and injection site. One should also inspect the injection site each time to ensure there has been no leakage. The fairest comparison would be done with daily injections and after a significant stabilization period. You can see that it's not exactly trivial to minimize all of the possible confounding variables. It might be easier — and more accurate — to send the product out to a lab for testing. Aren't compounding pharmacies required to perform such testing anyway? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Issues with Empower Test-CYP?
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