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Is Metformin a Miracle Drug ? : Nelson Vergel Explains
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<blockquote data-quote="Guided_by_Voices" data-source="post: 85479" data-attributes="member: 15235"><p>Nelson,</p><p> </p><p>Thanks a lot for putting this together. I made it all the way through and I learned a lot. A few comments:</p><p>- I think the question on whether it is beneficial for “non-diabetics” needs to take into account that the damage from diabetes has been shown to start well before blood sugar rises into “diabetic ranges”, and even before it starts to rise at all due to the insulin rise shown in the work of Dr. Kraft. </p><p>- If it turns out to have an mTOR inhibiting affect beyond what would come from its inhibition of insulin, then that could make it a sort of poor man’s rapamycin. </p><p>- There seems to be a lot of reports online that is has a pro-erectile affect beyond what could be accounted for in its well-studies actions, so that is likely to be of interest to many here.</p><p>- It will be interesting to see the results of the TAME study, although for the type of health events they are looking for, 5 years is a fairly short period of time to expect to see a large impact, but it will be interesting to see anyway.</p><p></p><p>I’m on a lower dose than discussed here and I am cycling it so that I take it primarily around higher carb meals and away from my heaviest activity days, so I’m interested to see how it goes. I’m also hoping for a noticeable anti-inflammatory effect for my knees so we will see. I'll be looking forward to the peptide discussion.</p></blockquote><p></p>
[QUOTE="Guided_by_Voices, post: 85479, member: 15235"] Nelson, Thanks a lot for putting this together. I made it all the way through and I learned a lot. A few comments: - I think the question on whether it is beneficial for “non-diabetics” needs to take into account that the damage from diabetes has been shown to start well before blood sugar rises into “diabetic ranges”, and even before it starts to rise at all due to the insulin rise shown in the work of Dr. Kraft. - If it turns out to have an mTOR inhibiting affect beyond what would come from its inhibition of insulin, then that could make it a sort of poor man’s rapamycin. - There seems to be a lot of reports online that is has a pro-erectile affect beyond what could be accounted for in its well-studies actions, so that is likely to be of interest to many here. - It will be interesting to see the results of the TAME study, although for the type of health events they are looking for, 5 years is a fairly short period of time to expect to see a large impact, but it will be interesting to see anyway. I’m on a lower dose than discussed here and I am cycling it so that I take it primarily around higher carb meals and away from my heaviest activity days, so I’m interested to see how it goes. I’m also hoping for a noticeable anti-inflammatory effect for my knees so we will see. I'll be looking forward to the peptide discussion. [/QUOTE]
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Is Metformin a Miracle Drug ? : Nelson Vergel Explains
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