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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Is lower LDL cholesterol associated with lower androgen and erectile dysfunction in men?
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<blockquote data-quote="Nelson Vergel" data-source="post: 142826" data-attributes="member: 3"><p>Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1304-1310. doi: 10.1016/j.numecd.2018.08.006. Epub 2018 Aug 31.</p><p></p><p><strong>Is lower low-density lipoprotein cholesterol associated with lower androgen and erectile dysfunction in men?</strong></p><p></p><p></p><p>Chen C1, Zhai H1, Huang G2, Cheng J1, Xia F1, Zhao L1, Chen Y1, Chen Y1, Han B1, Li Q1, Jiang B1, Wang N3, Lu Y4.</p><p></p><p>Abstract</p><p>BACKGROUND AND AIMS:</p><p>Therapeutic possibilities now exist to lower low-density lipoprotein cholesterol (LDL-C) to very low levels. However, substantial controversy remains in clinical practice with regard to its safety, and the question of whether low LDL-C levels per se may provoke adverse effects in humans arises. We aimed to explore the association of LDL-C with androgen and erectile dysfunction (ED) in a general population of men.</p><p></p><p>METHODS AND RESULTS:</p><p>A total of 4203 men without hormone replacement therapy were enrolled from 22 sites in East China. Total testosterone (T) and Free T were assessed. Free androgen index (FAI) was calculated. The IIEF-5 questionnaire was used to assess ED. We found that free T and FAI gradually and markedly increased with increasing LDL-C levels. Using linear regression, after adjusting for age, educational level, economic status, smoking status, drinking status, BMI, diabetes, and use of lipid-lowering medication, LDL-C was positively associated with free T (B = 0.175, 95% CI: 0.084, 0.266) and FAI (B = 0.064, 95% CI: 0.016, 0.112). Meanwhile, there was a U-shaped curvilinear relationship between LDL-C and prevalence of ED. In the logistic regression analysis, compared to those with LDL-C among the 10th-90th percentile, the ORs of ED in men in the lowest and highest deciles were 1.938 (95% CI: 1.121, 3.349) and 1.804 (95% CI: 1.117, 2.916), respectively.</p><p></p><p>CONCLUSION:</p><p>Lower LDL-C levels were significantly associated with lower free T and lower FAI in a general population of men. Moreover, both low and high levels of LDL-C might be risk factors for ED.</p><p></p><p></p><p></p><p>KEYWORDS:</p><p>Erectile dysfunction; Free androgen index; Low-density lipoprotein cholesterol; Sex steroids</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 142826, member: 3"] Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1304-1310. doi: 10.1016/j.numecd.2018.08.006. Epub 2018 Aug 31. [B]Is lower low-density lipoprotein cholesterol associated with lower androgen and erectile dysfunction in men?[/B] Chen C1, Zhai H1, Huang G2, Cheng J1, Xia F1, Zhao L1, Chen Y1, Chen Y1, Han B1, Li Q1, Jiang B1, Wang N3, Lu Y4. Abstract BACKGROUND AND AIMS: Therapeutic possibilities now exist to lower low-density lipoprotein cholesterol (LDL-C) to very low levels. However, substantial controversy remains in clinical practice with regard to its safety, and the question of whether low LDL-C levels per se may provoke adverse effects in humans arises. We aimed to explore the association of LDL-C with androgen and erectile dysfunction (ED) in a general population of men. METHODS AND RESULTS: A total of 4203 men without hormone replacement therapy were enrolled from 22 sites in East China. Total testosterone (T) and Free T were assessed. Free androgen index (FAI) was calculated. The IIEF-5 questionnaire was used to assess ED. We found that free T and FAI gradually and markedly increased with increasing LDL-C levels. Using linear regression, after adjusting for age, educational level, economic status, smoking status, drinking status, BMI, diabetes, and use of lipid-lowering medication, LDL-C was positively associated with free T (B = 0.175, 95% CI: 0.084, 0.266) and FAI (B = 0.064, 95% CI: 0.016, 0.112). Meanwhile, there was a U-shaped curvilinear relationship between LDL-C and prevalence of ED. In the logistic regression analysis, compared to those with LDL-C among the 10th-90th percentile, the ORs of ED in men in the lowest and highest deciles were 1.938 (95% CI: 1.121, 3.349) and 1.804 (95% CI: 1.117, 2.916), respectively. CONCLUSION: Lower LDL-C levels were significantly associated with lower free T and lower FAI in a general population of men. Moreover, both low and high levels of LDL-C might be risk factors for ED. KEYWORDS: Erectile dysfunction; Free androgen index; Low-density lipoprotein cholesterol; Sex steroids [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Is lower LDL cholesterol associated with lower androgen and erectile dysfunction in men?
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