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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Is LC-MS/MS the Magic Bullet? - What the Endocrinologist Should Know
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<blockquote data-quote="madman" data-source="post: 197812" data-attributes="member: 13851"><p><strong>Abstract</strong></p><p><strong></strong></p><p><strong><em>Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful tool that is changing the way we analyze steroids in the clinical laboratory. <u>It offers positive compound identification to enable the unequivocal identification of a compound free from interference</u>. </em></strong>LC-MS/MS is already opening up the field of steroid analysis in endocrinology and is providing new applications for individual steroids and panels of steroids in different clinical conditions. <strong><u><em>LC-MS/MS is now well-accepted technology and is increasingly being used to replace problematic immunoassay methods because of greater sensitivity and specificity</em></u><em>. Improved sample preparation, modern chromatography methods, and sensitive, faster scanning mass spectrometers have all played a role in improving LC-MS/MS.</em></strong><em> <strong>LC-MS/MS is also playing a key role in improving the quality of assays through the development of reference measurement procedures, characterization of reference materials, and multi-site calibration programs.</strong> </em>There is increasing interest in multiplexing steroid assays into panels of diagnostic tests to aid and improve the diagnosis and monitoring of disease.</p></blockquote><p></p>
[QUOTE="madman, post: 197812, member: 13851"] [B]Abstract [I]Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful tool that is changing the way we analyze steroids in the clinical laboratory. [U]It offers positive compound identification to enable the unequivocal identification of a compound free from interference[/U]. [/I][/B]LC-MS/MS is already opening up the field of steroid analysis in endocrinology and is providing new applications for individual steroids and panels of steroids in different clinical conditions. [B][U][I]LC-MS/MS is now well-accepted technology and is increasingly being used to replace problematic immunoassay methods because of greater sensitivity and specificity[/I][/U][I]. Improved sample preparation, modern chromatography methods, and sensitive, faster scanning mass spectrometers have all played a role in improving LC-MS/MS.[/I][/B][I] [B]LC-MS/MS is also playing a key role in improving the quality of assays through the development of reference measurement procedures, characterization of reference materials, and multi-site calibration programs.[/B] [/I]There is increasing interest in multiplexing steroid assays into panels of diagnostic tests to aid and improve the diagnosis and monitoring of disease. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Is LC-MS/MS the Magic Bullet? - What the Endocrinologist Should Know
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