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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Is free testosterone the main variable that matters in testosterone replacement?
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<blockquote data-quote="Gene Devine" data-source="post: 11774" data-attributes="member: 4"><p>Hi Cameron - You are correct in your assessment of Total versus Free Serum levels:</p><p></p><p>From our good Dr. John Crisler who I believe is one of our greatest minds in TRT for men:</p><p></p><p>TOTAL TESTOSTERONE</p><p>This is the assay your patients will most focus on, as will clinicians unpracticed in the art. Physicians who do not understand sex hormones will deny patients the testosterone supplementation they want--and need!--when Total T is at low-normal levels. Total T is important for titration of dosing, but its relevance is reduced in older men, by virtue of their increased serum concentrations of SHBG (and therefore lowered Bioavailable Testosterone), in favor of:</p><p></p><p></p><p>BIOAVAILABLE TESTOSTERONE</p><p>Where we get the “bang” for the hormonal buck, so to speak. This is the actual amount the body has available for use, as the concentration of hormone available within the capillary beds before the androgen receptor approximates the sum of the Free Testosterone plus that which is loosely bound to other carrier proteins in the blood, primarily albumin. If Bio T is not readily available, Free T may be a second choice substitute, as Bio T and Free T serum concentrations are usually well correlated. <u><strong>Bioavailable Testosterone is the gold standard for serum androgen evaluation.</strong></u></p><p></p><p>See attachment and print it out for your Doctor to read. </p><p></p><p>[ATTACH]1075[/ATTACH]</p></blockquote><p></p>
[QUOTE="Gene Devine, post: 11774, member: 4"] Hi Cameron - You are correct in your assessment of Total versus Free Serum levels: From our good Dr. John Crisler who I believe is one of our greatest minds in TRT for men: TOTAL TESTOSTERONE This is the assay your patients will most focus on, as will clinicians unpracticed in the art. Physicians who do not understand sex hormones will deny patients the testosterone supplementation they want--and need!--when Total T is at low-normal levels. Total T is important for titration of dosing, but its relevance is reduced in older men, by virtue of their increased serum concentrations of SHBG (and therefore lowered Bioavailable Testosterone), in favor of: BIOAVAILABLE TESTOSTERONE Where we get the “bang” for the hormonal buck, so to speak. This is the actual amount the body has available for use, as the concentration of hormone available within the capillary beds before the androgen receptor approximates the sum of the Free Testosterone plus that which is loosely bound to other carrier proteins in the blood, primarily albumin. If Bio T is not readily available, Free T may be a second choice substitute, as Bio T and Free T serum concentrations are usually well correlated. [U][B]Bioavailable Testosterone is the gold standard for serum androgen evaluation.[/B][/U] See attachment and print it out for your Doctor to read. [ATTACH]1075[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Is free testosterone the main variable that matters in testosterone replacement?
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