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Is dhea an androgen?
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<blockquote data-quote="Cataceous" data-source="post: 228823" data-attributes="member: 38109"><p>Going further into the <a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#As_an_androgen" target="_blank">Wiki article</a> you get the answer to the original question: Yes, DHEA is an androgen, albeit a weak one. It's also a weak estrogen.</p><p></p><p style="margin-left: 20px"><em>DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, increased oiliness of hair and skin, and mild acne. DHEA is potentiated locally via conversion into testosterone and dihydrotestosterone (DHT) in the skin and hair follicles. Women with complete androgen insensitivity syndrome (CAIS), who have a non-functional androgen receptor (AR) and are immune to the androgenic effects of DHEA and other androgens, have absent or only sparse/scanty pubic and axillary hair and body hair in general, demonstrating the role of DHEA and other androgens in body hair development at both adrenarche and pubarche.</em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Although it functions as an endogenous precursor to more potent androgens such as testosterone and DHT, DHEA has been found to possess some degree of androgenic activity in its own right, acting as a low affinity (Ki = 1 μM), weak partial agonist of the androgen receptor (AR). However, its intrinsic activity at the receptor is quite weak, and on account of that, due to competition for binding with full agonists like testosterone, it can actually behave more like an antagonist depending on circulating testosterone and dihydrotestosterone (DHT) levels, and hence, like an antiandrogen. However, its affinity for the receptor is very low, and for that reason, is unlikely to be of much significance under normal circumstances.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 228823, member: 38109"] Going further into the [URL='https://en.wikipedia.org/wiki/Dehydroepiandrosterone#As_an_androgen']Wiki article[/URL] you get the answer to the original question: Yes, DHEA is an androgen, albeit a weak one. It's also a weak estrogen. [INDENT][I]DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, increased oiliness of hair and skin, and mild acne. DHEA is potentiated locally via conversion into testosterone and dihydrotestosterone (DHT) in the skin and hair follicles. Women with complete androgen insensitivity syndrome (CAIS), who have a non-functional androgen receptor (AR) and are immune to the androgenic effects of DHEA and other androgens, have absent or only sparse/scanty pubic and axillary hair and body hair in general, demonstrating the role of DHEA and other androgens in body hair development at both adrenarche and pubarche.[/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]Although it functions as an endogenous precursor to more potent androgens such as testosterone and DHT, DHEA has been found to possess some degree of androgenic activity in its own right, acting as a low affinity (Ki = 1 μM), weak partial agonist of the androgen receptor (AR). However, its intrinsic activity at the receptor is quite weak, and on account of that, due to competition for binding with full agonists like testosterone, it can actually behave more like an antagonist depending on circulating testosterone and dihydrotestosterone (DHT) levels, and hence, like an antiandrogen. However, its affinity for the receptor is very low, and for that reason, is unlikely to be of much significance under normal circumstances.[/I][/INDENT] [/QUOTE]
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Is dhea an androgen?
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