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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Is “Enclomiphene Citrate” going to replace hCG in the USA?
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<blockquote data-quote="Cataceous" data-source="post: 219235" data-attributes="member: 38109"><p>Starting from a natural state, a guy taking clomiphene usually sees an increase in the rate of testosterone production. Even if SHBG doesn't change, we expect the increased production rate to raise free testosterone, which in turn pushes up total testosterone. It's common for the added estrogenic action of zuclomiphene to raise SHBG. This shouldn't affect the increase in free testosterone, but it means total testosterone is increased more than if SHBG hadn't changed. Conventional wisdom has been that increases in SHBG limit gains in free testosterone, but this is probably incorrect—because free testosterone should be pretty independent of SHBG as long as total testosterone is unconstrained.</p><p></p><p>"Supplementing" with exogenous testosterone can be rather complicated, but let's assume the most likely scenario, in which the usual negative HPTA feedback is saturated with excess testosterone. Normally estradiol is the larger contributor to this suppression, but it has been blocked by enclomiphene. In this case natural testosterone production still ceases and free testosterone is now a function of the dosing of the exogenous testosterone. If free testosterone is higher than pre-TRT then this may somewhat counteract the effect of zuclomiphene on SHBG. If SHBG goes down as a result then total testosterone also falls, but free testosterone is unaffected; free testosterone is the independent variable.</p><p></p><p>I don't see any reason why replacing clomiphene with enclomiphene in the above situation should produce different results, except for the possible variations in SHBG. It will be interesting and puzzling if enclomiphene is shown to be a viable replacement for hCG. I'm still betting against it at this point.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 219235, member: 38109"] Starting from a natural state, a guy taking clomiphene usually sees an increase in the rate of testosterone production. Even if SHBG doesn't change, we expect the increased production rate to raise free testosterone, which in turn pushes up total testosterone. It's common for the added estrogenic action of zuclomiphene to raise SHBG. This shouldn't affect the increase in free testosterone, but it means total testosterone is increased more than if SHBG hadn't changed. Conventional wisdom has been that increases in SHBG limit gains in free testosterone, but this is probably incorrect—because free testosterone should be pretty independent of SHBG as long as total testosterone is unconstrained. "Supplementing" with exogenous testosterone can be rather complicated, but let's assume the most likely scenario, in which the usual negative HPTA feedback is saturated with excess testosterone. Normally estradiol is the larger contributor to this suppression, but it has been blocked by enclomiphene. In this case natural testosterone production still ceases and free testosterone is now a function of the dosing of the exogenous testosterone. If free testosterone is higher than pre-TRT then this may somewhat counteract the effect of zuclomiphene on SHBG. If SHBG goes down as a result then total testosterone also falls, but free testosterone is unaffected; free testosterone is the independent variable. I don't see any reason why replacing clomiphene with enclomiphene in the above situation should produce different results, except for the possible variations in SHBG. It will be interesting and puzzling if enclomiphene is shown to be a viable replacement for hCG. I'm still betting against it at this point. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Is “Enclomiphene Citrate” going to replace hCG in the USA?
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