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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Is “Enclomiphene Citrate” going to replace hCG in the USA?
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<blockquote data-quote="Cataceous" data-source="post: 218461" data-attributes="member: 38109"><p>Clomid aka clomiphene consists of about 60% enclomiphene and 40% zuclomiphene. Enclomiphene is the isomer that selectively antagonizes estrogen receptors—and in particular those in the hypothalamus and pituitary. Zuclomiphene is estrogenic, selectively agonizing some estrogen receptors. Clearly enclomiphene is more potent than zuclomiphene with respect to the HPTA, as overall clomiphene stimulates rather than suppresses. However zuclomiphene is still potent; taking it by itself can effectively castrate a natural male, the same way taking estrogen does. In general it doesn't make sense for men to take zuclomiphene at all unless they really needed added estrogenic activity. </p><p></p><p>There is some degree of negative feedback at the hypothalamus from both estrogens and androgens. Enclomiphene reduces or eliminates the negative feedback from estrogens by blocking those receptors. At the pituitary, however, it appears there is minimal, if any negative feedback from androgens; the negative feedback is from estrogens. Therefore, in principle enclomiphene allows the pituitary to respond fully to whatever GnRH is delivered by the hypothalamus.</p><p></p><p>There are some lingering questions about the effects of androgens on the hypothalamus. Why is it possible for some men to have quite high endogenous testosterone with clomiphene monotherapy, when in contrast it seems few can sustain HPTA activity with concurrent TRT? Is it related to absolute levels of the hormones, or does it also involve how the levels change? Testosterone is naturally delivered in pulses. Natesto imitates this to an extent and Natesto is the only form of exogenous testosterone proven to allow continued HPTA activity. A further question: how much natural variability between men is there in the strength of negative androgen feedback at the hypothalamus? If there's wide variability then it could explain some of the unusual anecdotes.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 218461, member: 38109"] Clomid aka clomiphene consists of about 60% enclomiphene and 40% zuclomiphene. Enclomiphene is the isomer that selectively antagonizes estrogen receptors—and in particular those in the hypothalamus and pituitary. Zuclomiphene is estrogenic, selectively agonizing some estrogen receptors. Clearly enclomiphene is more potent than zuclomiphene with respect to the HPTA, as overall clomiphene stimulates rather than suppresses. However zuclomiphene is still potent; taking it by itself can effectively castrate a natural male, the same way taking estrogen does. In general it doesn't make sense for men to take zuclomiphene at all unless they really needed added estrogenic activity. There is some degree of negative feedback at the hypothalamus from both estrogens and androgens. Enclomiphene reduces or eliminates the negative feedback from estrogens by blocking those receptors. At the pituitary, however, it appears there is minimal, if any negative feedback from androgens; the negative feedback is from estrogens. Therefore, in principle enclomiphene allows the pituitary to respond fully to whatever GnRH is delivered by the hypothalamus. There are some lingering questions about the effects of androgens on the hypothalamus. Why is it possible for some men to have quite high endogenous testosterone with clomiphene monotherapy, when in contrast it seems few can sustain HPTA activity with concurrent TRT? Is it related to absolute levels of the hormones, or does it also involve how the levels change? Testosterone is naturally delivered in pulses. Natesto imitates this to an extent and Natesto is the only form of exogenous testosterone proven to allow continued HPTA activity. A further question: how much natural variability between men is there in the strength of negative androgen feedback at the hypothalamus? If there's wide variability then it could explain some of the unusual anecdotes. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Is “Enclomiphene Citrate” going to replace hCG in the USA?
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