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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Irritability and anxiety on Testosterone
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<blockquote data-quote="madman" data-source="post: 150749" data-attributes="member: 13851"><p><strong>Our <span style="color: rgb(184, 49, 47)">patent protected</span>, novel <span style="color: rgb(184, 49, 47)">TruT™</span> companion diagnostic framework provides <span style="color: rgb(44, 130, 201)">accurate determination</span><span style="color: rgb(184, 49, 47)"> of free testosterone concentrations</span>. <span style="color: rgb(44, 130, 201)">This algorithm is based on experimental data demonstrating that testosterone’s binding to SHBG is a multi-step process involving an allosteric interaction between the two binding sites on the SHBG dimer.</span></strong> <strong><span style="color: rgb(184, 49, 47)">Estimates of free testosterone derived incorporating the allosteric coupling of SHBG monomers within the dimer provide accurate determination of free testosterone</span> <span style="color: rgb(44, 130, 201)">without systematic deviation from values obtained using </span><span style="color: rgb(251, 160, 38)">equilibrium dialysis. </span></strong></p><p></p><p></p><p></p><p>Now getting back to your FT levels as you can see if we take your labs from 4/2019 when you had FT tested using <strong><span style="color: rgb(250, 197, 28)">Ultrafiltration</span></strong> which is the next best testing method when compared to the <span style="color: rgb(251, 160, 38)"><strong>gold standard Equilibrium Dialysis </strong></span>and than if we use the new calculated method using the <span style="font-size: 18px"><a href="https://tru-t.org/" target="_blank"><strong>TruT <span style="color: rgb(0, 0, 0)">Free Testosterone Calculator by</span> FPT</strong></a> <strong>(</strong></span><strong>which will be <span style="color: rgb(184, 49, 47)">comparable in accuracy</span> when <span style="color: rgb(184, 49, 47)">matched against</span> <span style="color: rgb(251, 160, 38)">Equilibrium Dialysis</span> or <span style="color: rgb(250, 197, 28)">Ultrafiltration</span>)</strong></p><p></p><p>Although you did not have SHBG tested on the (4/2019 labs) if we assume that your SHBG level would be somewhat similar to when it was tested on the( 6/2019 labs) 42.4 nmol/L (2 months later).....than if we take your<strong> TT 972 ng/dL (4/2019 labs)</strong>, <span style="color: rgb(184, 49, 47)"><strong>SHBG 42.4 nmol/L (6/2019 labs) </strong></span>and <span style="color: rgb(44, 130, 201)"><strong>Albumin 4.7 g/dL</strong></span> and use the newer calculated method <span style="color: rgb(184, 49, 47)"><strong>TruT </strong></span>than your <strong><span style="color: rgb(184, 49, 47)">FT level would be 30.92 ng/dL</span> (top end of the reference range <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span>) </strong>and than compare it to your <strong><span style="color: rgb(184, 49, 47)">FT level 30.62 ng/dL using the </span><span style="color: rgb(250, 197, 28)">Ultrafiltration method</span></strong><span style="color: rgb(184, 49, 47)"> <strong>they are an</strong></span> <strong><span style="color: rgb(184, 49, 47)">extremely close</span></strong> <span style="color: rgb(184, 49, 47)"><strong>match</strong></span> <strong><span style="color: rgb(184, 49, 47)">compared to the </span><span style="color: rgb(26, 188, 156)">dismal underestimation</span><span style="color: rgb(0, 0, 0)"> when using the</span> <span style="color: rgb(26, 188, 156)">Free T direct immunoassay </span><span style="color: rgb(0, 0, 0)">which is know to be</span> <span style="color: rgb(26, 188, 156)">inaccurate testing method</span> <span style="color: rgb(0, 0, 0)">that almost everyone on the forum relies on.</span></strong></p><p>[ATTACH=full]7602[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p><em><span style="color: rgb(0, 0, 0)">4/2019</span> (40mg, 250iu, .125ai MWF) [labs done Tu 12pm]</em></p><p><em>Test (LC/MS) <strong>972 </strong>[264.0-916.0]</em></p><p><em>FreeT (ultrafiltration) <strong>30.62</strong> [5.00-21.00]</em></p><p><em>E2 Sensitive <strong>13</strong> [8.0-35.0]</em></p><p><em>Free E2 Percent <strong>3.6</strong> [1.7-5.4]</em></p><p><em>Free E2 <strong>0.47</strong> [0.2-1.5]</em> </p><p></p><p></p><p></p><p></p><p>Most recent labs: </p><p></p><p><span style="color: rgb(0, 0, 0)">6/2019</span><span style="color: rgb(184, 49, 47)"> (</span>40mg, 250iu, no ai MWF) [labs done Monday AM before shot]</p><p>Test 908 [26-916]</p><p><strong><span style="color: rgb(26, 188, 156)">FreeT(direct)</span></strong> <strong><span style="color: rgb(26, 188, 156)">17.5</span></strong> [8.7-25.1]</p><p><strong><span style="color: rgb(184, 49, 47)">Tru-T</span> </strong>(Albumin 4.7) <strong><span style="color: rgb(184, 49, 47)">28.65</span></strong></p><p>E2 (Roche ECLIA) 41.5 [7.6-42.6] (I know wrong test but this test bundle was $100 cheaper than other options)</p><p>SHBG 42.4 [16.5-55.9]</p><p>HCT 52.5 [37.5-51.0] (haven't donated blood in ~6months)</p><p>DHT 19 [30-85] </p><p></p><p></p><p></p><p></p><p></p><p>Even when looking at your most recent labs above TT levels not drastically different <span style="color: rgb(26, 188, 156)"><strong>4/2019 -TT 972</strong></span> and<span style="color: rgb(250, 197, 28)"> <strong>6/2019-TT 908</strong> </span>notice the big difference between your<span style="color: rgb(184, 49, 47)"><strong> FT levels</strong></span> using the <strong><span style="color: rgb(26, 188, 156)">Free T direct immunoassay (known to be inaccurate)</span></strong> <strong><span style="color: rgb(26, 188, 156)">17.5</span></strong> <strong>[8.7-25.1]</strong> and the <span style="color: rgb(250, 197, 28)"><strong>Free T </strong></span><em><span style="color: rgb(250, 197, 28)"><strong>(ultrafiltration) 30.62 </strong></span><span style="color: rgb(0, 0, 0)"><strong>[5.00-21.00] </strong></span><span style="color: rgb(250, 197, 28)"><strong>(comparable to the </strong></span><span style="color: rgb(251, 160, 38)"><strong>gold standard equilibrium dialysis</strong></span><span style="color: rgb(250, 197, 28)"><strong>)</strong></span><span style="color: rgb(0, 0, 0)">.....</span><span style="color: rgb(26, 188, 156)"><strong>the Free T direct immunoassay underestimates</strong></span> <span style="color: rgb(0, 0, 0)">your levels which would have a huge impact on the effectiveness or lack thereof on ones protocol!</span></em></p></blockquote><p></p>
[QUOTE="madman, post: 150749, member: 13851"] [B]Our [COLOR=rgb(184, 49, 47)]patent protected[/COLOR], novel [COLOR=rgb(184, 49, 47)]TruT™[/COLOR] companion diagnostic framework provides [COLOR=rgb(44, 130, 201)]accurate determination[/COLOR][COLOR=rgb(184, 49, 47)] of free testosterone concentrations[/COLOR]. [COLOR=rgb(44, 130, 201)]This algorithm is based on experimental data demonstrating that testosterone’s binding to SHBG is a multi-step process involving an allosteric interaction between the two binding sites on the SHBG dimer.[/COLOR][/B][COLOR=rgb(184, 49, 47)] [/COLOR][B][COLOR=rgb(184, 49, 47)]Estimates of free testosterone derived incorporating the allosteric coupling of SHBG monomers within the dimer provide accurate determination of free testosterone[/COLOR] [COLOR=rgb(44, 130, 201)]without systematic deviation from values obtained using [/COLOR][COLOR=rgb(251, 160, 38)]equilibrium dialysis. [/COLOR][/B] Now getting back to your FT levels as you can see if we take your labs from 4/2019 when you had FT tested using [B][COLOR=rgb(250, 197, 28)]Ultrafiltration[/COLOR][/B] which is the next best testing method when compared to the [COLOR=rgb(251, 160, 38)][B]gold standard Equilibrium Dialysis [/B][/COLOR]and than if we use the new calculated method using the [SIZE=18px][URL='https://tru-t.org/'][B]TruT [COLOR=rgb(0, 0, 0)]Free Testosterone Calculator by[/COLOR] FPT[/B][/URL] [B]([/B][/SIZE][B]which will be [COLOR=rgb(184, 49, 47)]comparable in accuracy[/COLOR] when [COLOR=rgb(184, 49, 47)]matched against[/COLOR] [COLOR=rgb(251, 160, 38)]Equilibrium Dialysis[/COLOR] or [COLOR=rgb(250, 197, 28)]Ultrafiltration[/COLOR])[/B] Although you did not have SHBG tested on the (4/2019 labs) if we assume that your SHBG level would be somewhat similar to when it was tested on the( 6/2019 labs) 42.4 nmol/L (2 months later).....than if we take your[B] TT 972 ng/dL (4/2019 labs)[/B], [COLOR=rgb(184, 49, 47)][B]SHBG 42.4 nmol/L (6/2019 labs) [/B][/COLOR]and [COLOR=rgb(44, 130, 201)][B]Albumin 4.7 g/dL[/B][/COLOR] and use the newer calculated method [COLOR=rgb(184, 49, 47)][B]TruT [/B][/COLOR]than your [B][COLOR=rgb(184, 49, 47)]FT level would be 30.92 ng/dL[/COLOR] (top end of the reference range [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR]) [/B]and than compare it to your [B][COLOR=rgb(184, 49, 47)]FT level 30.62 ng/dL using the [/COLOR][COLOR=rgb(250, 197, 28)]Ultrafiltration method[/COLOR][/B][COLOR=rgb(184, 49, 47)] [B]they are an[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]extremely close[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B]match[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]compared to the [/COLOR][COLOR=rgb(26, 188, 156)]dismal underestimation[/COLOR][COLOR=rgb(0, 0, 0)] when using the[/COLOR][COLOR=rgb(184, 49, 47)] [/COLOR][COLOR=rgb(26, 188, 156)]Free T direct immunoassay [/COLOR][COLOR=rgb(0, 0, 0)]which is know to be[/COLOR][COLOR=rgb(184, 49, 47)] [/COLOR][COLOR=rgb(26, 188, 156)]inaccurate testing method[/COLOR][COLOR=rgb(184, 49, 47)] [/COLOR][COLOR=rgb(0, 0, 0)]that almost everyone on the forum relies on.[/COLOR][/B] [ATTACH=full]7602[/ATTACH] [I][COLOR=rgb(0, 0, 0)]4/2019[/COLOR][B][COLOR=rgb(184, 49, 47)] [/COLOR][/B](40mg, 250iu, .125ai MWF) [labs done Tu 12pm] Test (LC/MS) [B]972 [/B][264.0-916.0] FreeT (ultrafiltration) [B]30.62[/B] [5.00-21.00] E2 Sensitive [B]13[/B] [8.0-35.0] Free E2 Percent [B]3.6[/B] [1.7-5.4] Free E2 [B]0.47[/B] [0.2-1.5][/I] Most recent labs: [COLOR=rgb(0, 0, 0)]6/2019[/COLOR][COLOR=rgb(184, 49, 47)] ([/COLOR]40mg, 250iu, no ai MWF) [labs done Monday AM before shot] Test[B] [/B]908[B] [/B][26-916] [B][COLOR=rgb(26, 188, 156)]FreeT(direct)[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]17.5[/COLOR][/B] [8.7-25.1] [B][COLOR=rgb(184, 49, 47)]Tru-T[/COLOR][COLOR=rgb(226, 80, 65)] [/COLOR][/B](Albumin 4.7) [B][COLOR=rgb(184, 49, 47)]28.65[/COLOR][/B] E2 (Roche ECLIA) 41.5 [7.6-42.6] (I know wrong test but this test bundle was $100 cheaper than other options) SHBG 42.4 [16.5-55.9] HCT 52.5 [37.5-51.0] (haven't donated blood in ~6months) DHT 19 [30-85] Even when looking at your most recent labs above TT levels not drastically different [COLOR=rgb(26, 188, 156)][B]4/2019 -TT 972[/B][/COLOR] and[COLOR=rgb(250, 197, 28)] [B]6/2019-TT 908[/B] [/COLOR]notice the big difference between your[COLOR=rgb(184, 49, 47)][B] FT levels[/B][/COLOR] using the [B][COLOR=rgb(26, 188, 156)]Free T direct immunoassay (known to be inaccurate)[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]17.5[/COLOR][/B] [B][8.7-25.1][/B] and the [COLOR=rgb(250, 197, 28)][B]Free T [/B][/COLOR][I][COLOR=rgb(250, 197, 28)][B](ultrafiltration) 30.62 [/B][/COLOR][COLOR=rgb(0, 0, 0)][B][5.00-21.00] [/B][/COLOR][COLOR=rgb(250, 197, 28)][B](comparable to the [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]gold standard equilibrium dialysis[/B][/COLOR][COLOR=rgb(250, 197, 28)][B])[/B][/COLOR][COLOR=rgb(0, 0, 0)].....[/COLOR][COLOR=rgb(26, 188, 156)][B]the Free T direct immunoassay underestimates[/B][/COLOR][COLOR=rgb(250, 197, 28)][B] [/B][/COLOR][COLOR=rgb(0, 0, 0)]your levels which would have a huge impact on the effectiveness or lack thereof on ones protocol![/COLOR][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Irritability and anxiety on Testosterone
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