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Information here on why your doctor is right to be concerned about higher levels. Ignore those who would downplay the issue.


What worries me about the recommendations I've listened to is that some poor fellow is going to use this advice and think an Hct level in the mid 50s is perfectly reasonable and nothing should be done to correct this. ...  But for the vast majority of folks looking for functional longevity and compression of morbidity, the medical literature is quite clear a corrective action should be taken. In this thread I'll share some literature, resources to help inform TRT users and demonstrate that elevated Hct is not benign.


What is your TRT protocol? What are total testosterone and SHBG? Free testosterone measured with equilibrium dialysis or ultrafiltration would also be useful.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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