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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Iron Supplementation and Iron Testing Questions?
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<blockquote data-quote="FDV70" data-source="post: 213009" data-attributes="member: 43104"><p>The majority of research states that high hematocrit during Testosterone replacement does not present a definitive risk:</p><p>"No evidence exists that a high hematocrit is harmful and a direct cause of thrombosis; in addition, many conditions that lead to a very high hematocrit are not associated with thromboses." [<a href="https://www.hematologyandoncology.net/archives/january-2019/diagnosing-or-ruling-out-polycythemia-vera-in-patients-with-erythrocytosis/" target="_blank">Source</a>]</p><p></p><p>Large scale studies show no association between TRT and thromboembolism. The first study done in 2015 is here: [<a href="https://pubmed.ncbi.nlm.nih.gov/26205547/" target="_blank">Source</a>] A 2018 study that included six Randomized Controlled Trials (n = 2,236) and five observational studies (n = 1,249,640) is here: [<a href="https://pubmed.ncbi.nlm.nih.gov/30396049/" target="_blank">Source</a>] "There was no evidence of a statistically significant association between [venous thromboembolism] and testosterone."</p><p></p><p>"Several lines of evidence suggest that an isolated elevation in hematocrit does not, per se, lead to thrombosis. [...] Coronary blood flow is decreased in secondary erythrocytosis, but there is equivocal evidence as to whether the risk of coronary thrombosis is increased in patients with a high hematocrit." [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442963/" target="_blank">Source</a>]</p><p></p><p>"Increased Hct is associated with increased blood viscosity, reduced venous return and increased platelet adhesiveness. [...] Based on Endocrine Society Clinical Practice Guidelines, once a Hct > 54% is reached, TTh should either be discontinued, or therapeutic phlebotomy offered to reduce the risk of potential future thromboembolic events." However, "...few data support an increased risk of CV events resulting from testosterone-induced erythrocytosis." [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690890/" target="_blank">Source</a>]</p><p></p><p>That said, some guys have symptoms from high hematocrit. Headaches and breathlessness are two common ones. At 50, I don't think you have to donate nor do I think you will have symptoms.</p><p></p><p>If done exactly correctly, my protocol will elevate your ferritin and raise hemoglobin only a minimal amount. Even a couple guys who were inexact had only a rise of about 1 point. It starts to work after 3 days, and just about everyone is doing 4. We are seeing a consistent 8 to 10 points per day. Doing it after donating is ideal because it also eliminates the "rebound" effect where hemoglobin comes back up faster after donating. [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729915/" target="_blank">Source</a>] Check the main thread on this and post your findings here:</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/raising-ferritin-fast-a-how-to-not-a-question.24186[/URL]</p></blockquote><p></p>
[QUOTE="FDV70, post: 213009, member: 43104"] The majority of research states that high hematocrit during Testosterone replacement does not present a definitive risk: "No evidence exists that a high hematocrit is harmful and a direct cause of thrombosis; in addition, many conditions that lead to a very high hematocrit are not associated with thromboses." [[URL='https://www.hematologyandoncology.net/archives/january-2019/diagnosing-or-ruling-out-polycythemia-vera-in-patients-with-erythrocytosis/']Source[/URL]] Large scale studies show no association between TRT and thromboembolism. The first study done in 2015 is here: [[URL='https://pubmed.ncbi.nlm.nih.gov/26205547/']Source[/URL]] A 2018 study that included six Randomized Controlled Trials (n = 2,236) and five observational studies (n = 1,249,640) is here: [[URL='https://pubmed.ncbi.nlm.nih.gov/30396049/']Source[/URL]] "There was no evidence of a statistically significant association between [venous thromboembolism] and testosterone." "Several lines of evidence suggest that an isolated elevation in hematocrit does not, per se, lead to thrombosis. [...] Coronary blood flow is decreased in secondary erythrocytosis, but there is equivocal evidence as to whether the risk of coronary thrombosis is increased in patients with a high hematocrit." [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442963/']Source[/URL]] "Increased Hct is associated with increased blood viscosity, reduced venous return and increased platelet adhesiveness. [...] Based on Endocrine Society Clinical Practice Guidelines, once a Hct > 54% is reached, TTh should either be discontinued, or therapeutic phlebotomy offered to reduce the risk of potential future thromboembolic events." However, "...few data support an increased risk of CV events resulting from testosterone-induced erythrocytosis." [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690890/']Source[/URL]] That said, some guys have symptoms from high hematocrit. Headaches and breathlessness are two common ones. At 50, I don't think you have to donate nor do I think you will have symptoms. If done exactly correctly, my protocol will elevate your ferritin and raise hemoglobin only a minimal amount. Even a couple guys who were inexact had only a rise of about 1 point. It starts to work after 3 days, and just about everyone is doing 4. We are seeing a consistent 8 to 10 points per day. Doing it after donating is ideal because it also eliminates the "rebound" effect where hemoglobin comes back up faster after donating. [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729915/']Source[/URL]] Check the main thread on this and post your findings here: [URL unfurl="true"]https://www.excelmale.com/forum/threads/raising-ferritin-fast-a-how-to-not-a-question.24186[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Iron Supplementation and Iron Testing Questions?
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