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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Ipamorelin Dosage Discussion
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<blockquote data-quote="Nelson Vergel" data-source="post: 140107" data-attributes="member: 3"><p>Ipamorelin is a very effective growth hormone releasing agent.</p><p></p><p>Functioning as a GH secretagogue (Ghrelin analog), Ipamorelin binds to receptors in the brain and pituitary cells to cause the production and release of growth hormone. Not only does it stimulate the pituitary gland to release growth hormone, it also inhibits the release of somatostatin. Ipamorelin creates a more steady slow release of growth hormone and as such mimics the natural release of GH. In laboratory studies it is shown that Ipamorelin has a more stable release of GH than most other GHRPs. In studies previously done on animal test subjects, it was found that Ipamorelin has the ability to strengthen connective tissue and joints, bone strength, and metabolism.</p><p></p><p>•Type: Ghrelin agonist</p><p></p><p>•Available Dosage Form: Lyophilized powder for subcutaneous injection (must be reconstituted)</p><p></p><p>•Strengths: Compounding pharmacies may offer several different strengths and combinations. The most common Ipamorelin concentrations offered as a multi-dose injection are 6mg, and 15mg. Compounded ipamorelin 500mg tablets (ODTs) remain pending until the investigation is completed in 2018</p><p></p><p>•Protocol: 250mcg-1000mcg every day qhs for 3-6 months to reach short term goals. Ipamorelin can also be taken chronically at 250-500mcg qhs for age-management/wellness in aging patients. Starting dose of 300- 500 micrograms per day may be sufficient to improve lean mass and decrease fat without water retention, hyperglycemia, and joint pain.</p><p></p><p>•Uses (off-label): Ipamorelin has similar uses as Sermorelin. It is most commonly used in aging patients and/or patients who are undergoing body composition changes including loss of body fat. Ipamorelin is used to reverse age-related, maladaptive changes in body composition such as reduced lean body mass (muscle), increased total and visceral fat, and decreased bone mass. It also is reported to increase physical performance, benefit sleep, and enhance quality of life.</p><p></p><p>•Patient Type: Elderly patients who may not have optimal pituitary function due to aging; younger patients who can optimize hGH output; Patients on a weight-management program; patients requiring long term chronic treatment of GH</p><p></p><p><strong>Benefits:</strong></p><p></p><p>•Appears to be more effective than Sermorelin at increasing IGF-1</p><p></p><p>•Does not increase hunger unlike other ghrelin peptides</p><p></p><p>•Reduced risk of increasing cortisol and prolactin unlike other ghrelin peptides</p><p></p><p>•It does not shut down endogenous GH production upon cessation, unlike Sermorelin.</p><p></p><p>•Commonly prescribed by physicians who report positive outcomes in patients who want to lose weight and/or who do not respond adequately to Sermorelin</p><p></p><p>•Safe and effective in elderly patients who have decreased hGH production</p><p></p><p>•In studies done on animal test subjects, Ipamorelin has been found to increase the amount of lean muscle with the development of new muscle cells.</p><p></p><p>•It has also shown to possibly have a positive influence on the immune system. This positive effect is due to secondary actions of ghrelin on the body.</p><p></p><p>•In a few studies, ipamorelin has also been found to increase the natural sleep patterns of test animals.</p><p></p><p><strong>Negatives:</strong></p><p></p><p>While few side effects have been reported, below are some that have been mentioned anecdotally. These if real, are undoubtedly related to excessive hGH exposure and thus, dosage should be reduced.</p><p></p><p>Headache/lightheadedness</p><p></p><p>Water retention</p><p></p><p>Numbness in extremities</p><p></p><p>Tiredness</p><p></p><p>Decreased Insulin sensitivity</p><p></p><p>Carpal tunnel symptoms</p><p></p><p>Studies:</p><p></p><p><a href="https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=ipamorelin&btnG=" target="_blank">Google Scholar</a></p><p></p><p>Available in the US by prescription at <a href="https://www.empowerpharmacy.com/contact-us.html" target="_blank">Empower Pharmacy</a>. It comes in 15 mg vials ( 50 doses of 300 micrograms). Bacteriostatic water, syringes, and alcohol pads are provided free of charge with every shipped order. Prescriptions should be faxed as</p><p></p><p><em>Ipamorelin Acetate, 15 mg vial, 300 mcg/day, #3</em></p><p></p><p><a href="https://www.google.com/search?q=ipamorelin+excelmale.com+site:www.excelmale.com&sa=X&ved=2ahUKEwiZnMLdl4DjAhVOnKwKHW0WArUQrQIoBDAAegQIAxAN&biw=1795&bih=870" target="_blank"><em>More on Ipamorelin from ExcelMale.com</em></a></p><p></p><p>[ATTACH=full]6920[/ATTACH]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 140107, member: 3"] Ipamorelin is a very effective growth hormone releasing agent. Functioning as a GH secretagogue (Ghrelin analog), Ipamorelin binds to receptors in the brain and pituitary cells to cause the production and release of growth hormone. Not only does it stimulate the pituitary gland to release growth hormone, it also inhibits the release of somatostatin. Ipamorelin creates a more steady slow release of growth hormone and as such mimics the natural release of GH. In laboratory studies it is shown that Ipamorelin has a more stable release of GH than most other GHRPs. In studies previously done on animal test subjects, it was found that Ipamorelin has the ability to strengthen connective tissue and joints, bone strength, and metabolism. •Type: Ghrelin agonist •Available Dosage Form: Lyophilized powder for subcutaneous injection (must be reconstituted) •Strengths: Compounding pharmacies may offer several different strengths and combinations. The most common Ipamorelin concentrations offered as a multi-dose injection are 6mg, and 15mg. Compounded ipamorelin 500mg tablets (ODTs) remain pending until the investigation is completed in 2018 •Protocol: 250mcg-1000mcg every day qhs for 3-6 months to reach short term goals. Ipamorelin can also be taken chronically at 250-500mcg qhs for age-management/wellness in aging patients. Starting dose of 300- 500 micrograms per day may be sufficient to improve lean mass and decrease fat without water retention, hyperglycemia, and joint pain. •Uses (off-label): Ipamorelin has similar uses as Sermorelin. It is most commonly used in aging patients and/or patients who are undergoing body composition changes including loss of body fat. Ipamorelin is used to reverse age-related, maladaptive changes in body composition such as reduced lean body mass (muscle), increased total and visceral fat, and decreased bone mass. It also is reported to increase physical performance, benefit sleep, and enhance quality of life. •Patient Type: Elderly patients who may not have optimal pituitary function due to aging; younger patients who can optimize hGH output; Patients on a weight-management program; patients requiring long term chronic treatment of GH [B]Benefits:[/B] •Appears to be more effective than Sermorelin at increasing IGF-1 •Does not increase hunger unlike other ghrelin peptides •Reduced risk of increasing cortisol and prolactin unlike other ghrelin peptides •It does not shut down endogenous GH production upon cessation, unlike Sermorelin. •Commonly prescribed by physicians who report positive outcomes in patients who want to lose weight and/or who do not respond adequately to Sermorelin •Safe and effective in elderly patients who have decreased hGH production •In studies done on animal test subjects, Ipamorelin has been found to increase the amount of lean muscle with the development of new muscle cells. •It has also shown to possibly have a positive influence on the immune system. This positive effect is due to secondary actions of ghrelin on the body. •In a few studies, ipamorelin has also been found to increase the natural sleep patterns of test animals. [B]Negatives:[/B] While few side effects have been reported, below are some that have been mentioned anecdotally. These if real, are undoubtedly related to excessive hGH exposure and thus, dosage should be reduced. Headache/lightheadedness Water retention Numbness in extremities Tiredness Decreased Insulin sensitivity Carpal tunnel symptoms Studies: [URL='https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=ipamorelin&btnG=']Google Scholar[/URL] Available in the US by prescription at [URL='https://www.empowerpharmacy.com/contact-us.html']Empower Pharmacy[/URL]. It comes in 15 mg vials ( 50 doses of 300 micrograms). Bacteriostatic water, syringes, and alcohol pads are provided free of charge with every shipped order. Prescriptions should be faxed as [I]Ipamorelin Acetate, 15 mg vial, 300 mcg/day, #3[/I] [URL='https://www.google.com/search?q=ipamorelin+excelmale.com+site:www.excelmale.com&sa=X&ved=2ahUKEwiZnMLdl4DjAhVOnKwKHW0WArUQrQIoBDAAegQIAxAN&biw=1795&bih=870'][I]More on Ipamorelin from ExcelMale.com[/I][/URL] [ATTACH=full]6920[/ATTACH] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Ipamorelin Dosage Discussion
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