Investigating the Effects of Testosterone on the Human Immune System

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SciTalk: Investigating the Effects of Testosterone on the Human Immune System

Camila Consiglio is a recipient of the Michelson Prizes: Next Generation Grants

Camila Consiglio, Ph.D. Marie Skłodowska-Curie Postdoctoral Fellow, Women's and children's health, Karolinska Institutet

 

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Sex hormone signaling and regulation of immune function

SUMMARY Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine antigens, differ between males and females. The quest to uncover the mechanisms for biological sex differences in the immune system has intensified, with considerable literature pointing toward sex...

www.excelmale.com

 

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Immune system adaptation during gender-affirming testosterone treatment - Nature

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses in cisgender individuals.

www.nature.com

 

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Sex hormones modulate the immune system to influence disease risk differently, study finds

Researchers have uncovered how hormones profoundly affect our immune systems, explaining why men and women are affected by diseases differently.

www.sciencedaily.com

 

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Thread 'How Testosterone Levels Impact Men's Immunity: New Research Uncovers Sex Differences in Infection and Cancer Risk'

Sep 7, 2025

Sex differences play a crucial role in shaping human immune responses, influencing susceptibility to infections, cancer, and autoimmune diseases.

Overview of Sex-Based Immune Differences​

Females generally exhibit more robust immune responses than males, resulting in fewer severe infections and lower cancer rates. However, this heightened immunity makes females more prone to autoimmune diseases, where the immune system mistakenly targets the body's own tissues. Males, conversely, tend to have a lower immune response, making them more vulnerable to infections and...

• madman
• testosterone; immune system; health
• Replies: 2
• Forum: Health & Wellness