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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Injection frequency
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<blockquote data-quote="Cataceous" data-source="post: 167134" data-attributes="member: 38109"><p>One idea is that low SHBG enhances sensitivity to hormonal fluctuations, with unnatural hormonal variations being worse with respect to the ratio of free testosterone to free estradiol. "James" expands a little on the idea <a href="https://www.peaktestosterone.com/forum/index.php?topic=14375.msg128805#msg128805" target="_blank">here</a>. "I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG."</p><p></p><p>In any case, discard the notion that "testosterone is expelled so quickly". Injections supply testosterone at a slow and steady rate. On average testosterone must be "expelled", i.e. metabolized and cleared, at exactly this rate. This still leaves open the possibility of other clearance rate-related detrimental effects from low SHBG. For example, if there are disadvantages in having decreased total testosterone with the same free testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 167134, member: 38109"] One idea is that low SHBG enhances sensitivity to hormonal fluctuations, with unnatural hormonal variations being worse with respect to the ratio of free testosterone to free estradiol. "James" expands a little on the idea [URL='https://www.peaktestosterone.com/forum/index.php?topic=14375.msg128805#msg128805']here[/URL]. "I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG." In any case, discard the notion that "testosterone is expelled so quickly". Injections supply testosterone at a slow and steady rate. On average testosterone must be "expelled", i.e. metabolized and cleared, at exactly this rate. This still leaves open the possibility of other clearance rate-related detrimental effects from low SHBG. For example, if there are disadvantages in having decreased total testosterone with the same free testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Injection frequency
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