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After years of being on pellets, my wife reached out to Defy (I referred her to get the referral bonus).  What did they do?  They put her on T-cyp 50 mg/ml - .15 cc injection 2x per week plus bi-estrogen cream and progesterone at night.  She's doing very well on this protocol - far better than the pellets ever did.  She's never been on T-cream though.