madman
Super Moderator
Influence of testosterone substitution on glycemic control and endothelial markers in men with newly diagnosed functional hypogonadism and type 2 diabetes mellitus: a randomized controlled trial
Irina Khripun , Sergey Vorobyev , Igor Belouso , Michel Kogana and Michael Zitzmann
a Federal State Budget Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Health of the Russian Federation, Rostov-on-Don, Russia; b Center for Reproductive Medicine and Andrology/Operative Andrology, University Clinics Muenster, Muenster, Germany
Conclusion
TRT in men with functional hypogonadism with T2DM leads to a decrease in BMI and WC. TRT in men with T2DM and functional hypogonadism leads to a significant improvement in carbohydrate metabolism, namely improving insulin resistance, lowering fasting blood glucose levels and, ultimately, HbA1c. In men with T2DM and androgen deficiency, TRT is accompanied by a decrease in the levels of adipohormones, such as leptin and resistin, which, together with a reduction of EnD markers and indicators of inflammation (ICAM-1, p-selectin and CRP), seems to facilitate a reduction in cardiovascular risk.
Irina Khripun , Sergey Vorobyev , Igor Belouso , Michel Kogana and Michael Zitzmann
a Federal State Budget Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Health of the Russian Federation, Rostov-on-Don, Russia; b Center for Reproductive Medicine and Andrology/Operative Andrology, University Clinics Muenster, Muenster, Germany
Conclusion
TRT in men with functional hypogonadism with T2DM leads to a decrease in BMI and WC. TRT in men with T2DM and functional hypogonadism leads to a significant improvement in carbohydrate metabolism, namely improving insulin resistance, lowering fasting blood glucose levels and, ultimately, HbA1c. In men with T2DM and androgen deficiency, TRT is accompanied by a decrease in the levels of adipohormones, such as leptin and resistin, which, together with a reduction of EnD markers and indicators of inflammation (ICAM-1, p-selectin and CRP), seems to facilitate a reduction in cardiovascular risk.
