Very interesting. Given this from the article:
"...previous research has focused on evaluating the changes in endothelial function after treatment with statins. Their pleiotropic mechanism of action (anti-inflammatory,antioxidant) appears to improve endothelial dysfunction as
observed in numerous studies [187,188], independently from their lipid-lowering property..."
I wonder if administering statins to otherwise normally healthy people would confer some prophylactic/protective effect long term. (?). I've actually seen this proposed for consideration in some scientific literature but nothing conclusive. Similarly, as the use of metformin as an adjunct to longevity regimen.
Then we have: "...the role of genetic and epigenetic manipulation being under
rigorous investigation..." It's amazing how much scientific research is under rigorous investigation, yet we get decades of parallel studies and metanalysis and little clinical application. I say get on with it, power to the endothelium!
