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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Increase in CVD in Men on TRT
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<blockquote data-quote="Jinzang" data-source="post: 144659" data-attributes="member: 12925"><p>A new study tracked men on TRT for five years and tracked cardiovascular events. It found about a 20% increased risk in men on TRT, mostly during the first two years. The <a href="https://www.amjmed.com/article/S0002-9343(19)30281-5/fulltext?rss=yes" target="_blank">abstract</a> says:</p><p></p><p>"Using the UK Clinical Practice Research Datalink (CPRD), we formed a cohort of men aged 45 years or older with low testosterone levels and no evidence of hypogonadotropic or testicular disease, between 1995 and 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) of a composite of ischemic stroke/transient ischemic attack and myocardial infarction were estimated using time-dependent Cox proportional hazards models, comparing current use of TRT with nonuse."</p><p></p><p>"The cohort included 15,401 men. During 71,541 person-years of follow-up, 850 patients experienced an ischemic stroke/transient ischemic attack /myocardial infarction (crude incidence rate 1.19 (95% CI 1.11–1.27) per 100 persons per year). Compared with nonuse, current use of TRT was associated with an increased risk of the composite outcome (HR 1.21; 95% CI 1.00–1.46). This risk was highest in the first six months to two years of continuous TRT use (HR 1.35; 95% CI 1.01–1.79), as well as among men aged 45–59 years (HR 1.44; 95% CI 1.07–1.92)."</p><p></p><p>"TRT may increase the risk of cardiovascular events in aging men with low testosterone levels, particularly in the first 2 years of use. In the absence of identifiable causes of hypogonadism, TRT should be initiated with caution among aging men with low testosterone levels."</p></blockquote><p></p>
[QUOTE="Jinzang, post: 144659, member: 12925"] A new study tracked men on TRT for five years and tracked cardiovascular events. It found about a 20% increased risk in men on TRT, mostly during the first two years. The [URL='https://www.amjmed.com/article/S0002-9343(19)30281-5/fulltext?rss=yes']abstract[/URL] says: "Using the UK Clinical Practice Research Datalink (CPRD), we formed a cohort of men aged 45 years or older with low testosterone levels and no evidence of hypogonadotropic or testicular disease, between 1995 and 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) of a composite of ischemic stroke/transient ischemic attack and myocardial infarction were estimated using time-dependent Cox proportional hazards models, comparing current use of TRT with nonuse." "The cohort included 15,401 men. During 71,541 person-years of follow-up, 850 patients experienced an ischemic stroke/transient ischemic attack /myocardial infarction (crude incidence rate 1.19 (95% CI 1.11–1.27) per 100 persons per year). Compared with nonuse, current use of TRT was associated with an increased risk of the composite outcome (HR 1.21; 95% CI 1.00–1.46). This risk was highest in the first six months to two years of continuous TRT use (HR 1.35; 95% CI 1.01–1.79), as well as among men aged 45–59 years (HR 1.44; 95% CI 1.07–1.92)." "TRT may increase the risk of cardiovascular events in aging men with low testosterone levels, particularly in the first 2 years of use. In the absence of identifiable causes of hypogonadism, TRT should be initiated with caution among aging men with low testosterone levels." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Increase in CVD in Men on TRT
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