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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism
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<blockquote data-quote="tareload" data-source="post: 220104"><p>Best you can do at the moment is bracket your calculated fT using Vermeulen and Tru-T if you didn't use LC/MS+ED/UF to measure. For higher SHBG, that range is going to be pretty large.</p><p></p><p>And if you did use the "correct" fT test, is the result accurate? Stay tuned as [USER=13851]@madman[/USER] had told us.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/calculate-free-testosterone-with-trut-by-fpt.18468/post-189341[/URL]</p><p></p><p></p><p><img src="https://www.excelmale.com/forum/attachments/1603342765919-png.11197/" class="bbImage" alt="" data-url="https://www.excelmale.com/forum/attachments/1603342765919-png.11197/" style="" /></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/harmonized-reference-ranges-for-total-and-free-t-levels.24940/post-218745[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/response-from-labcorp-about-their-incorrect-unit-usages-for-their-free-testosterone-direct-test.22716/post-194717[/URL]</p><p></p><p>[URL unfurl="true"]https://forums.t-nation.com/t/realistic-trt-recomp-progress/253389/3311[/URL]</p><p></p><p>From this post as summary of how the math works out in an "easy" to understand example:</p><p><em>In summary, a poor guy with high SHBG:</em></p><p> <em>Total T = 1077 ng/dL</em></p><p> <em>SHBG = 151 nmol/L</em></p><ul> <li data-xf-list-type="ul"><em>“Direct” RIA free T comes back = 0.72 ng/dL (<strong>0.067% of total T</strong>)</em></li> <li data-xf-list-type="ul"><em>Calculated free T by Vermuelen = 7.57 ng/dL (<strong>0.7% of free T</strong>)</em></li> <li data-xf-list-type="ul"><em>Calculated free T by Tru-T = 25.3 ng/dL (<strong>2.35% of free T</strong>)</em></li> <li data-xf-list-type="ul"><em>Actual free T as measured by equilibrium dialysis probably 5-6 ng/dL (<strong>0.46-56% of free T</strong>)</em></li> </ul><p><em>So what’s the average guy to do if he really wants to understand his free T status? You can even argue about the validity of indirect vs direct equilbrium dialysis measurements and which one is correct if they don’t match. In short, it gets complicated.</em></p><p></p><p> <em>EDIT: as I posted below, if you take the RIA result and multiply by 6.7:</em></p><p> <em>0.72 ng/dL * 6.7 = 4.8 ng/dL which is very close to the range of 5-6 ng/dL I estimated would be shown via equilbrium dialysis. So if you want to convert your free T (via direct RIA) number to what it would be if your physician actually had ordered an appropriate test, then multiply by 7 not 10.</em></p></blockquote><p></p>
[QUOTE="tareload, post: 220104"] Best you can do at the moment is bracket your calculated fT using Vermeulen and Tru-T if you didn't use LC/MS+ED/UF to measure. For higher SHBG, that range is going to be pretty large. And if you did use the "correct" fT test, is the result accurate? Stay tuned as [USER=13851]@madman[/USER] had told us. [URL unfurl="true"]https://www.excelmale.com/forum/threads/calculate-free-testosterone-with-trut-by-fpt.18468/post-189341[/URL] [IMG]https://www.excelmale.com/forum/attachments/1603342765919-png.11197/[/IMG] [URL unfurl="true"]https://www.excelmale.com/forum/threads/harmonized-reference-ranges-for-total-and-free-t-levels.24940/post-218745[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/response-from-labcorp-about-their-incorrect-unit-usages-for-their-free-testosterone-direct-test.22716/post-194717[/URL] [URL unfurl="true"]https://forums.t-nation.com/t/realistic-trt-recomp-progress/253389/3311[/URL] From this post as summary of how the math works out in an "easy" to understand example: [I]In summary, a poor guy with high SHBG:[/I] [I]Total T = 1077 ng/dL[/I] [I]SHBG = 151 nmol/L[/I] [LIST] [*][I]“Direct” RIA free T comes back = 0.72 ng/dL ([B]0.067% of total T[/B])[/I] [*][I]Calculated free T by Vermuelen = 7.57 ng/dL ([B]0.7% of free T[/B])[/I] [*][I]Calculated free T by Tru-T = 25.3 ng/dL ([B]2.35% of free T[/B])[/I] [*][I]Actual free T as measured by equilibrium dialysis probably 5-6 ng/dL ([B]0.46-56% of free T[/B])[/I] [/LIST] [I]So what’s the average guy to do if he really wants to understand his free T status? You can even argue about the validity of indirect vs direct equilbrium dialysis measurements and which one is correct if they don’t match. In short, it gets complicated.[/I] [I]EDIT: as I posted below, if you take the RIA result and multiply by 6.7:[/I] [I]0.72 ng/dL * 6.7 = 4.8 ng/dL which is very close to the range of 5-6 ng/dL I estimated would be shown via equilbrium dialysis. So if you want to convert your free T (via direct RIA) number to what it would be if your physician actually had ordered an appropriate test, then multiply by 7 not 10.[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism
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