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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism
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<blockquote data-quote="madman" data-source="post: 219160" data-attributes="member: 13851"><p><strong>Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism (2022)</strong></p><p>[MEDIA=youtube]pnFPf024lPg[/MEDIA]</p><p></p><p><em><strong>Shalender Bhasin, M.D.</strong>, Professor of Medicine at Harvard Medical School and Director, Boston Claude D. Pepper Older Americans Independence Center; Director, Brigham Research Assay Core Laboratory; Director, Research Program in Men's Health: Aging and Metabolism; Co-Director, The Center for Transgender Health at Brigham and Women's Hospital, presented <strong>"Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism" </strong>at Endocrinology Grand Rounds on March 2, 2022.</em></p><p></p><p></p><p></p><p></p><p>[USER=3]@Nelson Vergel[/USER]</p><p></p><p><strong>Questions/Comments</strong></p><p><strong></strong></p><p><strong>58:03-1:14:40</strong></p><p><strong></strong></p><p><strong><em>* So I want to thank you for spending your hour with me and for letting me share my thoughts that have been percolating in my head for 35 years</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>1:02:10-1:05:48</strong></p><p></p><p><em><strong>* Equilibrium Dialysis/Ensemble Allostery Model (EAM)</strong></em></p><p></p><p><strong><em>* using our ensemble allostery model we have turned that into an algorithm and it provides a much closer approximation of the Equilibrium Dialysis, especially in the physiologic range and extending slightly into the supra-physiologic range we haven't validated it when people have levels that are very supraphysiologic</em></strong></p><p><strong><em></em></strong></p><p><strong><em>* we completely discount estradiol levels, similarly, we discount DHT levels and the same thing as with Albumin, Albumin you know the literature says Albumin binds to testosterone with a micromolar affinity and it is oversimplified and completely incorrect and we had so much difficulty publishing that paper but what we've shown using mnr studies we have shown that there are 9 binding sites for testosterone and these binding sites also bind free fatty acids, a whole variety of things and there's also allosteric interaction so amongst the binding proteins most are multimeric but Albumin is the one that is a monomeric protein but it has 9 binding sites and there is allostery between those binding sites some of them have a quite high binding affinity of testosterone</em></strong></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/allosterically-coupled-multi-site-binding-of-t-to-human-serum-albumin.22102/[/URL]</p><p></p><p></p><p></p><p></p><p></p><p><strong><em>[ATTACH=full]20152[/ATTACH]</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 219160, member: 13851"] [B]Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism (2022)[/B] [MEDIA=youtube]pnFPf024lPg[/MEDIA] [I][B]Shalender Bhasin, M.D.[/B], Professor of Medicine at Harvard Medical School and Director, Boston Claude D. Pepper Older Americans Independence Center; Director, Brigham Research Assay Core Laboratory; Director, Research Program in Men's Health: Aging and Metabolism; Co-Director, The Center for Transgender Health at Brigham and Women's Hospital, presented [B]"Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism" [/B]at Endocrinology Grand Rounds on March 2, 2022.[/I] [USER=3]@Nelson Vergel[/USER] [B]Questions/Comments 58:03-1:14:40 [I]* So I want to thank you for spending your hour with me and for letting me share my thoughts that have been percolating in my head for 35 years[/I] 1:02:10-1:05:48[/B] [I][B]* Equilibrium Dialysis/Ensemble Allostery Model (EAM)[/B][/I] [B][I]* using our ensemble allostery model we have turned that into an algorithm and it provides a much closer approximation of the Equilibrium Dialysis, especially in the physiologic range and extending slightly into the supra-physiologic range we haven't validated it when people have levels that are very supraphysiologic * we completely discount estradiol levels, similarly, we discount DHT levels and the same thing as with Albumin, Albumin you know the literature says Albumin binds to testosterone with a micromolar affinity and it is oversimplified and completely incorrect and we had so much difficulty publishing that paper but what we've shown using mnr studies we have shown that there are 9 binding sites for testosterone and these binding sites also bind free fatty acids, a whole variety of things and there's also allosteric interaction so amongst the binding proteins most are multimeric but Albumin is the one that is a monomeric protein but it has 9 binding sites and there is allostery between those binding sites some of them have a quite high binding affinity of testosterone[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/allosterically-coupled-multi-site-binding-of-t-to-human-serum-albumin.22102/[/URL] [B][I][ATTACH type="full" alt="Screenshot (11352).png"]20152[/ATTACH][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Improving Diagnostic Accuracy and Treatment Decisions in Men with Hypogonadism
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