Sildenafil (Viagra, Revatio) may be a candidate drug to prevent or treat Alzheimer's disease, new research suggested.
Across 6 years of follow-up, sildenafil users were 69% less likely to develop Alzheimer's disease than non-sildenafil users (HR 0.31, 95% CI 0.25-0.39, P<1 × 10-8), a large case-control analysis of insurance claims showed.
Sildenafil also emerged as a potential disease risk modifier in an analysis of drugs that might be repurposed for Alzheimer's, reported Feixiong Cheng, PhD, of the Cleveland Clinic Genomic Medicine Institute, and co-authors.
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