ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Imbalance of testosterone/estradiol promotes male CHD development
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 260847" data-attributes="member: 38109"><p>I recently came across <a href="https://pubmed.ncbi.nlm.nih.gov/22766718/" target="_blank">this article</a>. It's not new, but the search function doesn't turn up previous discussions about it on ExcelMale.</p><p></p><h3><p style="margin-left: 20px">Imbalance of testosterone/estradiol promotes male CHD development</p> </h3> <p style="margin-left: 20px"><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+HY&cauthor_id=22766718" target="_blank">Hong-Yun Zheng</a> <a href="https://pubmed.ncbi.nlm.nih.gov/22766718/#full-view-affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=22766718" target="_blank">Yan Li</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Dai+W&cauthor_id=22766718" target="_blank">Wen Dai</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Wei+CD&cauthor_id=22766718" target="_blank">Chuan-Dong Wei</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Sun+KS&cauthor_id=22766718" target="_blank">Kai-Sheng Sun</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Tong+YQ&cauthor_id=22766718" target="_blank">Yong-Qing Tong</a></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong><span style="font-size: 18px">Abstract</span></strong></p> <p style="margin-left: 20px"><strong>Objective: </strong>Testosterone is either neutral or has a harmful effect on the male cardiovascular system. But the role of imbalance of testosterone (T) and estrogen (E2) (T/E2 ratio) in male CHD has been less studied. This study was carried out with the purpose of evaluating the relationship between T/E2 ratio and CHD.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Methods: </strong>Fifty-five male CHD patients (aged 61.25 ± 3.44) and 60 age-matched controls (aged 59.54 ± 1.44) were selected in this research.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Results: </strong>Compared with control group, levels of both serum T and E2 decreased, but only E2 had statistical significance (P=0.001). The normal testosterone (T)/estradiol (E2) ratio is 1.7 ± 0.12, but the ratio of T/E2 (3.28 ± 0.58) changed significantly in men with CHD group (P<0.05). With the imbalance of T/E2 ratio in CHD group, we further used a linear and multiple regression methods to analyze the correlation between sex hormones and CHD risk factors. The results showed serum T was positively associated with TG (r=0.439, P<0.01) and D-dimer (r=0.258, P<0.05), but negatively associated with HDL-C (r=-0.267, P<0.05) and Hs-CRP (r=-0.214, P<0.05). However, E2 was highly positive associated with TG (r=0.783, P<0.01) and HDL-C (r=0.515, P<0.01), but was negative related with LDL-C (r=-0.219, P<0.05), TC/LDL (r=-0.236, P<0.05) and D-dimer. Multiple linear regression method also showed the same results between E2 and HDL-C (P=0.020), LDL-C (P=0.000), which showed E2's protective role in cases. However, T/E2's effect is more significative than E2's, and the values between T/E2 and index are HDL-C (r=-0.624, P<0.01), LDL-C (r=0.348, P<0.01), TC/HDL (r=0.237, P<0.05), Hs-CRP (r=0.248, P<0.05) and D-dimer (r=0.249, P<0.05). Multiple linear regression method also showed the positive relationship between T/E2 and HDL-C (P=0.000), D-dimer (P=0.000), and negative relationships between T/E2 and TC (P=0.000), TG (P=0.000) or HDL/LDL (P=0.000).</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Conclusion: </strong><u>The balance of T/E2 ratio, rather than the absolute levels of androgens, is crucial in modulating the effect of androgens on CHD in males</u>.</p><p></p><p>It's some food for thought for guys with high testosterone who might use AIs to push estradiol down to "normal".</p></blockquote><p></p>
[QUOTE="Cataceous, post: 260847, member: 38109"] I recently came across [URL='https://pubmed.ncbi.nlm.nih.gov/22766718/']this article[/URL]. It's not new, but the search function doesn't turn up previous discussions about it on ExcelMale. [HEADING=2][INDENT]Imbalance of testosterone/estradiol promotes male CHD development[/INDENT][/HEADING] [INDENT][URL='https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+HY&cauthor_id=22766718']Hong-Yun Zheng[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/22766718/#full-view-affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=22766718']Yan Li[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Dai+W&cauthor_id=22766718']Wen Dai[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Wei+CD&cauthor_id=22766718']Chuan-Dong Wei[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Sun+KS&cauthor_id=22766718']Kai-Sheng Sun[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Tong+YQ&cauthor_id=22766718']Yong-Qing Tong[/URL][/INDENT] [INDENT][/INDENT] [INDENT][B][SIZE=18px]Abstract[/SIZE][/B][/INDENT] [INDENT][B]Objective: [/B]Testosterone is either neutral or has a harmful effect on the male cardiovascular system. But the role of imbalance of testosterone (T) and estrogen (E2) (T/E2 ratio) in male CHD has been less studied. This study was carried out with the purpose of evaluating the relationship between T/E2 ratio and CHD.[/INDENT] [INDENT][/INDENT] [INDENT][B]Methods: [/B]Fifty-five male CHD patients (aged 61.25 ± 3.44) and 60 age-matched controls (aged 59.54 ± 1.44) were selected in this research.[/INDENT] [INDENT][/INDENT] [INDENT][B]Results: [/B]Compared with control group, levels of both serum T and E2 decreased, but only E2 had statistical significance (P=0.001). The normal testosterone (T)/estradiol (E2) ratio is 1.7 ± 0.12, but the ratio of T/E2 (3.28 ± 0.58) changed significantly in men with CHD group (P<0.05). With the imbalance of T/E2 ratio in CHD group, we further used a linear and multiple regression methods to analyze the correlation between sex hormones and CHD risk factors. The results showed serum T was positively associated with TG (r=0.439, P<0.01) and D-dimer (r=0.258, P<0.05), but negatively associated with HDL-C (r=-0.267, P<0.05) and Hs-CRP (r=-0.214, P<0.05). However, E2 was highly positive associated with TG (r=0.783, P<0.01) and HDL-C (r=0.515, P<0.01), but was negative related with LDL-C (r=-0.219, P<0.05), TC/LDL (r=-0.236, P<0.05) and D-dimer. Multiple linear regression method also showed the same results between E2 and HDL-C (P=0.020), LDL-C (P=0.000), which showed E2's protective role in cases. However, T/E2's effect is more significative than E2's, and the values between T/E2 and index are HDL-C (r=-0.624, P<0.01), LDL-C (r=0.348, P<0.01), TC/HDL (r=0.237, P<0.05), Hs-CRP (r=0.248, P<0.05) and D-dimer (r=0.249, P<0.05). Multiple linear regression method also showed the positive relationship between T/E2 and HDL-C (P=0.000), D-dimer (P=0.000), and negative relationships between T/E2 and TC (P=0.000), TG (P=0.000) or HDL/LDL (P=0.000).[/INDENT] [INDENT][/INDENT] [INDENT][B]Conclusion: [/B][U]The balance of T/E2 ratio, rather than the absolute levels of androgens, is crucial in modulating the effect of androgens on CHD in males[/U].[/INDENT] It's some food for thought for guys with high testosterone who might use AIs to push estradiol down to "normal". [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Imbalance of testosterone/estradiol promotes male CHD development
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top