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<blockquote data-quote="Matt73" data-source="post: 236330" data-attributes="member: 44494"><p>I'm a 53 year old man in good health. I've been using a compounded testosterone cream 20-25 mg per day for a couple of years due to low bioavailable T. In 2019, I was experiencing anxiety, insomnia, low energy and some chronic GI issues. Here was my blood work in 2019:</p><p>total T 528 ng/dl (250-1100)</p><p>free T 47.1 pg/ml (46-224)</p><p>bioavail. T 90.7 ng/dl (110-575)</p><p>SHBG 54 nmol/L (10-50) </p><p>DHT 65 ng/dl (16-79)</p><p>estradiol 22 pg/ml (<39)</p><p></p><p>Since then, I have done many things to improve my health (supplements, eradicating chronic infections, detoxification, the testosterone cream, etc). In the past 10 months, I also added intermittent fasting/low carb diet and strength training (I had already done lots of cardio training). This has lead to a 15 pound weight loss despite gains in strength and muscle; I am more fit now than I have been in at least 20 years. GI issues and energy levels are much improved/resolved. I still have some anxiety and insomnia, for which I use 5 mg of edible THC at night (legal in my state.) My overall goals now are optimizing my vitality and longevity/healthspan.</p><p></p><p>My recent blood work has me puzzled and I would love some help with a few questions. Here are labs from 9/22 (units and ranges are the same as above)</p><p></p><p>total T 848</p><p>free T 48.4</p><p>bioavail. T 110</p><p>SHBG 89</p><p>DHT 129</p><p>estradiol 18</p><p>TSH 6.08</p><p></p><p>I recently started 30 mg Armour thyroid to deal with the elevated TSH. </p><p></p><p>In addition to weighing in on my specific questions, I'd love any other comments anyone has:</p><p></p><p>1) Why is my SHBG so much higher than it was before? I don't think I am deficient on any important minerals as I take lots of supplements and my liver is in good shape.</p><p></p><p>2) Why is my DHT so much higher than it was before? Is that a problem? (I had already lost most of the hair on the top of my head by 2019, before I started T).</p><p></p><p>3) Would switching to taking more T cream fewer days per week be effective at lowering the SHBG and increasing the bioavailable T? Or would it be smart to switch to an injectable form of T and do it fewer days per week (I'd rather stick with cream but I am willing to do sub-cut. injections if it would be the best move)?</p><p></p><p>4) Any ideas/thoughts about lifestyle, supplement or medication interventions that would improve this picture?</p><p></p><p>Thanks so much for any helpful comments and suggestions!</p></blockquote><p></p>
[QUOTE="Matt73, post: 236330, member: 44494"] I'm a 53 year old man in good health. I've been using a compounded testosterone cream 20-25 mg per day for a couple of years due to low bioavailable T. In 2019, I was experiencing anxiety, insomnia, low energy and some chronic GI issues. Here was my blood work in 2019: total T 528 ng/dl (250-1100) free T 47.1 pg/ml (46-224) bioavail. T 90.7 ng/dl (110-575) SHBG 54 nmol/L (10-50) DHT 65 ng/dl (16-79) estradiol 22 pg/ml (<39) Since then, I have done many things to improve my health (supplements, eradicating chronic infections, detoxification, the testosterone cream, etc). In the past 10 months, I also added intermittent fasting/low carb diet and strength training (I had already done lots of cardio training). This has lead to a 15 pound weight loss despite gains in strength and muscle; I am more fit now than I have been in at least 20 years. GI issues and energy levels are much improved/resolved. I still have some anxiety and insomnia, for which I use 5 mg of edible THC at night (legal in my state.) My overall goals now are optimizing my vitality and longevity/healthspan. My recent blood work has me puzzled and I would love some help with a few questions. Here are labs from 9/22 (units and ranges are the same as above) total T 848 free T 48.4 bioavail. T 110 SHBG 89 DHT 129 estradiol 18 TSH 6.08 I recently started 30 mg Armour thyroid to deal with the elevated TSH. In addition to weighing in on my specific questions, I'd love any other comments anyone has: 1) Why is my SHBG so much higher than it was before? I don't think I am deficient on any important minerals as I take lots of supplements and my liver is in good shape. 2) Why is my DHT so much higher than it was before? Is that a problem? (I had already lost most of the hair on the top of my head by 2019, before I started T). 3) Would switching to taking more T cream fewer days per week be effective at lowering the SHBG and increasing the bioavailable T? Or would it be smart to switch to an injectable form of T and do it fewer days per week (I'd rather stick with cream but I am willing to do sub-cut. injections if it would be the best move)? 4) Any ideas/thoughts about lifestyle, supplement or medication interventions that would improve this picture? Thanks so much for any helpful comments and suggestions! [/QUOTE]
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