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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
IGF-1 came back very elevated. I'm panicking. How concerned should I be?
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<blockquote data-quote="eyeheartny" data-source="post: 114792" data-attributes="member: 18882"><p><u><strong>Background</strong></u></p><ul> <li data-xf-list-type="ul">I'm 36. On TRT for six years. 6'2", 215lbs.</li> <li data-xf-list-type="ul">Have had my GP manage my TRT and have never gotten specialist care to get dialed in. I'm in the process of signing up with Defy Medical to have Dr. Saya manage my TRT.</li> <li data-xf-list-type="ul">My GP has had me on 50,000 IU per week of Vitamin D2 after I came back low in December. I was supplementing with additional Vit D (5k IU per day) for a while. I'll explain why this is relevant below.</li> <li data-xf-list-type="ul">I've had a history of cancer; in 2015 I had a rare soft-tissue sarcoma removed that had clearly been there a while.</li> <li data-xf-list-type="ul">I'm on approximately 150-175mg/week of testosterone cypionate, injected EOD. I go back and forth between SubQ and IM.</li> <li data-xf-list-type="ul">I've messed around with lowering my E2 via exemestane before and have been off of it for the last month as I prepare to start working with Defy.</li> </ul><p><strong><u>Diet</u></strong></p><p><strong><u></u></strong></p><ul> <li data-xf-list-type="ul">I've eaten a high-protein diet for years, with a lot of that coming from red meat, poultry, fish, eggs, and cheese. I can't tolerate whey/casein protein but I get a lot of animal protein and have for a very long time.</li> </ul><p><strong><u>Current Situation</u></strong></p><p></p><ul> <li data-xf-list-type="ul">The labs they ordered came back on Friday. I'm still waiting for E2.</li> <li data-xf-list-type="ul">I'll include the major values but the IGF-1 is what's freaking me out. Based on my history and also my understanding of IGF-1's role in tumor growth, I'm in a total panic.</li> <li data-xf-list-type="ul">I'm concerned about acromegaly in addition to other long-term effects of elevated IGF-1.</li> <li data-xf-list-type="ul">No one has tested my IGF-1 before, and I'm concerned that I may have had pituitary issues that caused my low testosterone in the first place, and that for all these years I've had undiagnosed problems that the exogenous t</li> </ul><p><strong><u>Questions</u></strong></p><ul> <li data-xf-list-type="ul">How concerning is this elevated IGF-1 level? I'm very concerned about developing/having acromegaly but am wondering if others here have had elevated IGF-1 and were okay.</li> <li data-xf-list-type="ul">How much of a role could exogenous testosterone play in this elevated level?</li> <li data-xf-list-type="ul">If the exogenous T is elevating my IGF-1, how much of a risk could that be causing for me in terms of future cancer risk/developing acrogmegaly?</li> </ul><p></p><p><u><strong>Labs (drawn at LabCorp)</strong></u></p><p></p><ul> <li data-xf-list-type="ul">Testosterone 644 ng/dL Ref Range: 296-916</li> <li data-xf-list-type="ul">Free Testosterone 25.3 pg/mL Ref Range: 8.7-25.1</li> <li data-xf-list-type="ul">DHEA Sulfate 354.8 ug/dL Ref Range: 102.6-416.3</li> <li data-xf-list-type="ul">LH <0.2 mIU/mL Ref Range: 1.7-8.6</li> <li data-xf-list-type="ul">PSA 0.6 ng/mL 0.0-4.0</li> <li data-xf-list-type="ul">SHBG 23.3 nmol/L 16.5-55.9</li> <li data-xf-list-type="ul"><u><strong>IGF-1 419 ng/mL 83-233</strong></u></li> </ul><p>I've done a search here and have seen a few threads on elevated IGF-1, but I wanted to post my own and get feedback. If any of you have any experiences your IGF-1 being elevated, I'd be grateful for you to share your stories/experiences as well.</p></blockquote><p></p>
[QUOTE="eyeheartny, post: 114792, member: 18882"] [U][B]Background[/B][/U] [LIST] [*]I'm 36. On TRT for six years. 6'2", 215lbs. [*]Have had my GP manage my TRT and have never gotten specialist care to get dialed in. I'm in the process of signing up with Defy Medical to have Dr. Saya manage my TRT. [*]My GP has had me on 50,000 IU per week of Vitamin D2 after I came back low in December. I was supplementing with additional Vit D (5k IU per day) for a while. I'll explain why this is relevant below. [*]I've had a history of cancer; in 2015 I had a rare soft-tissue sarcoma removed that had clearly been there a while. [*]I'm on approximately 150-175mg/week of testosterone cypionate, injected EOD. I go back and forth between SubQ and IM. [*]I've messed around with lowering my E2 via exemestane before and have been off of it for the last month as I prepare to start working with Defy. [/LIST] [B][U]Diet [/U][/B] [LIST] [*]I've eaten a high-protein diet for years, with a lot of that coming from red meat, poultry, fish, eggs, and cheese. I can't tolerate whey/casein protein but I get a lot of animal protein and have for a very long time. [/LIST] [B][U]Current Situation[/U][/B] [LIST] [*]The labs they ordered came back on Friday. I'm still waiting for E2. [*]I'll include the major values but the IGF-1 is what's freaking me out. Based on my history and also my understanding of IGF-1's role in tumor growth, I'm in a total panic. [*]I'm concerned about acromegaly in addition to other long-term effects of elevated IGF-1. [*]No one has tested my IGF-1 before, and I'm concerned that I may have had pituitary issues that caused my low testosterone in the first place, and that for all these years I've had undiagnosed problems that the exogenous t [/LIST] [B][U]Questions[/U][/B] [LIST] [*]How concerning is this elevated IGF-1 level? I'm very concerned about developing/having acromegaly but am wondering if others here have had elevated IGF-1 and were okay. [*]How much of a role could exogenous testosterone play in this elevated level? [*]If the exogenous T is elevating my IGF-1, how much of a risk could that be causing for me in terms of future cancer risk/developing acrogmegaly? [/LIST] [U][B]Labs (drawn at LabCorp)[/B][/U] [LIST] [*]Testosterone 644 ng/dL Ref Range: 296-916 [*]Free Testosterone 25.3 pg/mL Ref Range: 8.7-25.1 [*]DHEA Sulfate 354.8 ug/dL Ref Range: 102.6-416.3 [*]LH <0.2 mIU/mL Ref Range: 1.7-8.6 [*]PSA 0.6 ng/mL 0.0-4.0 [*]SHBG 23.3 nmol/L 16.5-55.9 [*][U][B]IGF-1 419 ng/mL 83-233[/B][/U] [/LIST] I've done a search here and have seen a few threads on elevated IGF-1, but I wanted to post my own and get feedback. If any of you have any experiences your IGF-1 being elevated, I'd be grateful for you to share your stories/experiences as well. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
IGF-1 came back very elevated. I'm panicking. How concerned should I be?
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