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Message: <blockquote data-quote="DragonBits" data-source="post: 129551" data-attributes="member: 18023">Metformin reduces IGF-1 signalling, what confuses me is that related to IFG-1 levels?  There is an IGF-1 binding protein which also seems to get increased.So I wondered can you increase GF/IGF-1 while metformin reduces the signally pathway (negative effects) of IGF-1?As far as the tradeoff between "sacrifice a few years to get all the benefits while I'm alive" , I think it depend on how old you are right now. At age 66 and average life expectancy of 76, I don't have a lot of years to trade. <img src="https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f642.png" class="smilie smilie--emoji" loading="lazy" width="64" height="64" alt=":)" title="Smile    :)"  data-smilie="1"data-shortname=":)" />   And at age 30-50, maybe they will come up with new methods to extend life.</blockquote>