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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
IFG-1, IGF-1 signaling, good or bad?
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<blockquote data-quote="DragonBits" data-source="post: 129551" data-attributes="member: 18023"><p>Metformin reduces IGF-1 signalling, what confuses me is that related to IFG-1 levels? There is an IGF-1 binding protein which also seems to get increased.</p><p></p><p>So I wondered can you increase GF/IGF-1 while metformin reduces the signally pathway (negative effects) of IGF-1?</p><p></p><p>As far as the tradeoff between "sacrifice a few years to get all the benefits while I'm alive" , I think it depend on how old you are right now. At age 66 and average life expectancy of 76, I don't have a lot of years to trade. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /> And at age 30-50, maybe they will come up with new methods to extend life.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 129551, member: 18023"] Metformin reduces IGF-1 signalling, what confuses me is that related to IFG-1 levels? There is an IGF-1 binding protein which also seems to get increased. So I wondered can you increase GF/IGF-1 while metformin reduces the signally pathway (negative effects) of IGF-1? As far as the tradeoff between "sacrifice a few years to get all the benefits while I'm alive" , I think it depend on how old you are right now. At age 66 and average life expectancy of 76, I don't have a lot of years to trade. :) And at age 30-50, maybe they will come up with new methods to extend life. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
IFG-1, IGF-1 signaling, good or bad?
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