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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
IFG-1, IGF-1 signaling, good or bad?
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<blockquote data-quote="Gman86" data-source="post: 129550" data-attributes="member: 15043"><p>From my understanding, it's one of those hormones you absolutely want in the sweet spot, no more, no less. Too high of IGF-1 levels will actually decrease life span. It obviously has a ton of benefits, but when too high, it will actually decrease longevity. Low levels of IGF-1 are linked to longevity. </p><p></p><p>But it's all a balancing act with hormones. I personally would prefer to have IGF-1 levels in the upper normal range for all of the benefits it has, and am willing to sacrifice a few years to get all the benefits while I'm alive, like increased healing, regeneration of cells, increased lipolysis ( fat burning ), increased bone density, improved sleep, better mood/ sense of well being, improved cognition and decreased risk of cardiovascular disease. </p><p></p><p>What they are finding out more and more every year is the importance of insulin sensitivity. Insulin resistance seems to be the basis of most chronic disease. From my understanding, high growth hormone levels decrease insulin sensitivity. That's why bodybuilders that abuse HGH can have high blood sugar levels, and eventually become diabetic. So maybe one of the reasons why high growth hormone levels are associated with decreased longevity is because of this issue with insulin sensitivity. On the other hand, that's exactly why Metformin is being labeled as an "anti-aging" drug. It's because it improves insulin sensitivity. </p><p></p><p>I'm pretty sure you cannot increase GH levels, while lowering IGF-1 levels. Here's how it works. GH is secreted by the anterior pituitary gland into the blood stream, which then stimulates the liver to produce IGF-1. So anytime GH is increased, I would imagine it would just stimulate the liver to produce more IGF-1. I could be wrong though. </p><p></p><p>Bottom line though, growth hormone and IGF-1 levels are something you absolutely want to keep optimal, but definitely don't want too high. From my research, it seems like the consequences of having higher than normal levels of HGH are more dire than say testosterone or estrogen, for example.</p></blockquote><p></p>
[QUOTE="Gman86, post: 129550, member: 15043"] From my understanding, it's one of those hormones you absolutely want in the sweet spot, no more, no less. Too high of IGF-1 levels will actually decrease life span. It obviously has a ton of benefits, but when too high, it will actually decrease longevity. Low levels of IGF-1 are linked to longevity. But it's all a balancing act with hormones. I personally would prefer to have IGF-1 levels in the upper normal range for all of the benefits it has, and am willing to sacrifice a few years to get all the benefits while I'm alive, like increased healing, regeneration of cells, increased lipolysis ( fat burning ), increased bone density, improved sleep, better mood/ sense of well being, improved cognition and decreased risk of cardiovascular disease. What they are finding out more and more every year is the importance of insulin sensitivity. Insulin resistance seems to be the basis of most chronic disease. From my understanding, high growth hormone levels decrease insulin sensitivity. That's why bodybuilders that abuse HGH can have high blood sugar levels, and eventually become diabetic. So maybe one of the reasons why high growth hormone levels are associated with decreased longevity is because of this issue with insulin sensitivity. On the other hand, that's exactly why Metformin is being labeled as an "anti-aging" drug. It's because it improves insulin sensitivity. I'm pretty sure you cannot increase GH levels, while lowering IGF-1 levels. Here's how it works. GH is secreted by the anterior pituitary gland into the blood stream, which then stimulates the liver to produce IGF-1. So anytime GH is increased, I would imagine it would just stimulate the liver to produce more IGF-1. I could be wrong though. Bottom line though, growth hormone and IGF-1 levels are something you absolutely want to keep optimal, but definitely don't want too high. From my research, it seems like the consequences of having higher than normal levels of HGH are more dire than say testosterone or estrogen, for example. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
IFG-1, IGF-1 signaling, good or bad?
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