ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
If endogenous thyroid peaks at night/early am, why do we take exogenous during the day?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Gianluca" data-source="post: 278804" data-attributes="member: 15469"><p>According to this study, Thyroid level are at the highest between 10pm and 10am, why then everyone takes it during the day? wouldn't make sense to take the first dose at night before bed, and second right after waking up? I may want to try this actually.</p><p></p><p></p><h3>Free Triiodothyronine Has a Distinct Circadian Rhythm That Is Delayed but Parallels Thyrotropin Levels</h3><p></p><h3></h3><h3>Abstract</h3><p><strong>Context:</strong> TSH is known to have a circadian rhythm, but the relationship between this and any rhythm in T4 and T3 has not been clearly demonstrated.</p><p><strong>Objective:</strong> With a view to optimizing thyroid hormone replacement therapy, we have used modern assays for free T4 (FT4) and free T3 (FT3) to investigate circadian rhythmicity.</p><p><strong>Setting:</strong> The study was performed at a university hospital.</p><p><strong>Design and Subjects:</strong> This was a cross-sectional study in 33 healthy individuals with 24-h blood sampling (TSH in 33 and FT4 and FT3 in 29 individuals) and cosinor analysis.</p><p><strong>Results:</strong> Of the individuals, 100% showed a sinusoidal signal in TSH, for FT4 76%, and for FT3 86% (<em>P</em> < 0.05). For FT4 and FT3, the amplitude was low. For TSH the acrophase occurred at a clock time of 0240 h, and for FT3 approximately 90 minutes later at 0404 h. The group cosinor model predicts that TSH hormone levels remain above the mesor between 2020 and 0820 h, and for FT3 from 2200–1000 h. Cross correlation of FT3 with TSH showed that the peak correlation occurred with a delay of 0.5–2.5 h. When time-adjusted profiles of TSH and FT3 were compared, there was a strong correlation between FT3 and TSH levels (ρ = 0.80; <em>P</em> < 0.0001). In contrast, cross correlation revealed no temporal relationship between FT4 and TSH.</p><p></p><p></p><p></p><p><strong>Conclusions:</strong> FT3 shows a circadian rhythm with a periodicity that lags behind TSH, suggesting that the periodic rhythm of FT3 is due to the proportion of T3 derived from the thyroid. Optimizing thyroid hormone replacement may need to take these rhythms into account.</p><p></p><p></p><p>[URL unfurl="true"]https://academic.oup.com/jcem/article/93/6/2300/2598837[/URL]</p></blockquote><p></p>
[QUOTE="Gianluca, post: 278804, member: 15469"] According to this study, Thyroid level are at the highest between 10pm and 10am, why then everyone takes it during the day? wouldn't make sense to take the first dose at night before bed, and second right after waking up? I may want to try this actually. [HEADING=2]Free Triiodothyronine Has a Distinct Circadian Rhythm That Is Delayed but Parallels Thyrotropin Levels[/HEADING] [HEADING=2][/HEADING] [HEADING=2]Abstract[/HEADING] [B]Context:[/B] TSH is known to have a circadian rhythm, but the relationship between this and any rhythm in T4 and T3 has not been clearly demonstrated. [B]Objective:[/B] With a view to optimizing thyroid hormone replacement therapy, we have used modern assays for free T4 (FT4) and free T3 (FT3) to investigate circadian rhythmicity. [B]Setting:[/B] The study was performed at a university hospital. [B]Design and Subjects:[/B] This was a cross-sectional study in 33 healthy individuals with 24-h blood sampling (TSH in 33 and FT4 and FT3 in 29 individuals) and cosinor analysis. [B]Results:[/B] Of the individuals, 100% showed a sinusoidal signal in TSH, for FT4 76%, and for FT3 86% ([I]P[/I] < 0.05). For FT4 and FT3, the amplitude was low. For TSH the acrophase occurred at a clock time of 0240 h, and for FT3 approximately 90 minutes later at 0404 h. The group cosinor model predicts that TSH hormone levels remain above the mesor between 2020 and 0820 h, and for FT3 from 2200–1000 h. Cross correlation of FT3 with TSH showed that the peak correlation occurred with a delay of 0.5–2.5 h. When time-adjusted profiles of TSH and FT3 were compared, there was a strong correlation between FT3 and TSH levels (ρ = 0.80; [I]P[/I] < 0.0001). In contrast, cross correlation revealed no temporal relationship between FT4 and TSH. [B]Conclusions:[/B] FT3 shows a circadian rhythm with a periodicity that lags behind TSH, suggesting that the periodic rhythm of FT3 is due to the proportion of T3 derived from the thyroid. Optimizing thyroid hormone replacement may need to take these rhythms into account. [URL unfurl="true"]https://academic.oup.com/jcem/article/93/6/2300/2598837[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
If endogenous thyroid peaks at night/early am, why do we take exogenous during the day?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top