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Elevated E2 also causes issues within the thyroid. I believe with thyroid binding globulin and the conversion of T4 to T3. Obv the level that’s “too high” and causes these types of issues is gonna be different for everyone, but all hormones need to be in balance. U’ll never find a hormone that it’s ok to just let go very high or very low. Everything in the body works within a balance system. E2 is obv no exception