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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
I Haven’t Slept in 4 years. What to Do?
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<blockquote data-quote="Cataceous" data-source="post: 195236" data-attributes="member: 38109"><p>I think I'll stick to my 0.75 mg. The potential suppressive effect on the HPTA matters less to those on TRT, but taking high doses is an experiment with unknown consequences.</p><p></p><p style="margin-left: 20px"><em>In describing his research on melatonin Bentley is quoted stating; “<strong>It is a powerful hormone and yet people don’t realize that it’s as powerful as any steroid</strong>. I’m sure that many people who take it wouldn’t take steroids glibly. It could have a multitude of effects on the underlying physiology of an organism but we know so little about how it interacts with other hormone systems”. Bentley and Tsutsui have presented their important research on GnIH at the prestigious National Academy of Sciences and have followed up with a number of studies and publications confirming these complex interactions and risks. Since the discovery of GnIH in 2000 of this “new hormone”, the reproduction puzzle has been brought one step closer to being solved. <strong>We now know that GnRH “switches on gonads” and GnIH “switches off gonads”. <u>Melatonin increases the production of GnIH</u>.</strong> In a recent study by the research team, birds given injected melatonin had triple the levels of GnIH in their body as a result. Genetic models involving melatonin’s effects confirms that melatonin increases the messenger RNA needed to produce GnIH. The studies in bird mammalian models confirmed that melatonin binds directly to neurons in the hypothalamus brain tissue which resulted in increased production of GnIH. The end effect was a decrease in size and function of the testes and ovaries.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>In a 2012 study by Tsutsui he wrote; “The discovery of GnIH has fundamentally changed our understanding of hypothalamic control of reproduction”. What is even more troublesome is the recognition that these receptors which are responsible for transporting peptides in the hypothalamus have fibers branching to multiple areas of the human brain. These areas are involved in basically every physiological and behavioral process imaginable. <strong>Thus melatonin will likely be found in the future to affect a multitude of physiological systems other than just reproduction via the GnIH mechanism, some positive and some negative</strong>.</em></p><p>[<a href="https://www.kidsoc.org/2012/10/18/the-dangers-of-melatonin-in-children-a-problem-of-overuse-by-parents/" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 195236, member: 38109"] I think I'll stick to my 0.75 mg. The potential suppressive effect on the HPTA matters less to those on TRT, but taking high doses is an experiment with unknown consequences. [INDENT][I]In describing his research on melatonin Bentley is quoted stating; “[B]It is a powerful hormone and yet people don’t realize that it’s as powerful as any steroid[/B]. I’m sure that many people who take it wouldn’t take steroids glibly. It could have a multitude of effects on the underlying physiology of an organism but we know so little about how it interacts with other hormone systems”. Bentley and Tsutsui have presented their important research on GnIH at the prestigious National Academy of Sciences and have followed up with a number of studies and publications confirming these complex interactions and risks. Since the discovery of GnIH in 2000 of this “new hormone”, the reproduction puzzle has been brought one step closer to being solved. [B]We now know that GnRH “switches on gonads” and GnIH “switches off gonads”. [U]Melatonin increases the production of GnIH[/U].[/B] In a recent study by the research team, birds given injected melatonin had triple the levels of GnIH in their body as a result. Genetic models involving melatonin’s effects confirms that melatonin increases the messenger RNA needed to produce GnIH. The studies in bird mammalian models confirmed that melatonin binds directly to neurons in the hypothalamus brain tissue which resulted in increased production of GnIH. The end effect was a decrease in size and function of the testes and ovaries.[/I][/INDENT] [INDENT][I] [/I][/INDENT] [INDENT][I]In a 2012 study by Tsutsui he wrote; “The discovery of GnIH has fundamentally changed our understanding of hypothalamic control of reproduction”. What is even more troublesome is the recognition that these receptors which are responsible for transporting peptides in the hypothalamus have fibers branching to multiple areas of the human brain. These areas are involved in basically every physiological and behavioral process imaginable. [B]Thus melatonin will likely be found in the future to affect a multitude of physiological systems other than just reproduction via the GnIH mechanism, some positive and some negative[/B].[/I][/INDENT] [[URL='https://www.kidsoc.org/2012/10/18/the-dangers-of-melatonin-in-children-a-problem-of-overuse-by-parents/']R[/URL]] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
I Haven’t Slept in 4 years. What to Do?
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