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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
I am on week 5-6 anxiety comes and goes
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<blockquote data-quote="madman" data-source="post: 240508" data-attributes="member: 13851"><p><strong>Androgen therapy and erythrocytosis</strong></p><p></p><p><em><strong>*‘Erythrocytosis’ is formally defined as a hematocrit 25% higher than expected for an individual's height and weight [39]. </strong>The term ‘polycythemia’ is often used interchangeably but refers to any hematological cell excess rather than erythrocytes specifically. <strong>Erythrocytosis is suspected when hemoglobin is above 185 g/L or the hematocrit greater than 52% in a man, or above 165 g/L and 48% respectively, in a woman [40]. In men on testosterone therapy, the Endocrine Society defines erythrocytosis as hematocrit greater than 54%</strong></em></p><p></p><p></p><p><strong><em>*Erythrocytosis confers an increased blood viscosity and concerns arise from the potential increased risk of thromboembolic events including myocardial infarction and cerebrovascular accidents.</em></strong></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/management-of-erythrocytosis-in-men-receiving-trt.26412/[/URL]</p><p></p><p></p><p></p><p></p><p><strong>Regarding those struggling with <a href="https://www.discountedlabs.com/blog/what-you-should-know-about-the-main-side-effect-of-testosterone" target="_blank">high hematocrit</a> here is my reply from another thread:</strong></p><p></p><p>As you can see your RBCs/hemoglobin/hematocrit is elevated which is a common side-effect when using exogenous T, especially when running higher FT levels let alone peak--->trough levels can have a significant impact.</p><p></p><p>When using exogenous T RBCs, hemoglobin and hematocrit will increase within the 1st month and can take anywhere from 9-12 months to reach peak levels.</p><p></p><p>T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).</p><p></p><p>Other factors such as sleep apnea, smoking, asthma, COPD can have a negative impact on hematocrit.</p><p></p><p>Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.</p><p></p><p>3–18% with transdermal administration and up to 44% with injection.</p><p></p><p>In most cases when using injectable T <u><strong><em>high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)</em></strong></u> will have a big impact on increasing HCT.</p><p></p><p>Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given.</p><p></p><p><strong><em>As again </em></strong><em><strong>running very high TT/FT levels will have a stronger impact on driving up HCT.</strong></em></p><p></p><p>Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that <em><strong>the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.</strong></em></p><p></p><p>Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels.</p><p></p><p><strong><em>How high an FT level you are running is critical.</em></strong></p><p></p><p>It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are <em><strong>running too high an FT level</strong></em><strong><em>.</em></strong></p><p></p><p>Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such.</p><p></p><p>If you are struggling with such blood markers then in most cases finding the<em><strong> lowest FT level you can run while still maintaining the beneficial effects </strong></em>may very well be the solution.</p><p></p><p>Easier said than done as many men on trt tend to do better running higher-end FT levels within reason.</p><p></p><p>Mind you some are lucky and never have an issue or levels tend to stabilize over time.</p><p></p><p>Others will continue to struggle until the cows come home.</p><p></p><p>Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube!</p></blockquote><p></p>
[QUOTE="madman, post: 240508, member: 13851"] [B]Androgen therapy and erythrocytosis[/B] [I][B]*‘Erythrocytosis’ is formally defined as a hematocrit 25% higher than expected for an individual's height and weight [39]. [/B]The term ‘polycythemia’ is often used interchangeably but refers to any hematological cell excess rather than erythrocytes specifically. [B]Erythrocytosis is suspected when hemoglobin is above 185 g/L or the hematocrit greater than 52% in a man, or above 165 g/L and 48% respectively, in a woman [40]. In men on testosterone therapy, the Endocrine Society defines erythrocytosis as hematocrit greater than 54%[/B][/I] [B][I]*Erythrocytosis confers an increased blood viscosity and concerns arise from the potential increased risk of thromboembolic events including myocardial infarction and cerebrovascular accidents.[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/management-of-erythrocytosis-in-men-receiving-trt.26412/[/URL] [B]Regarding those struggling with [URL='https://www.discountedlabs.com/blog/what-you-should-know-about-the-main-side-effect-of-testosterone']high hematocrit[/URL] here is my reply from another thread:[/B] As you can see your RBCs/hemoglobin/hematocrit is elevated which is a common side-effect when using exogenous T, especially when running higher FT levels let alone peak--->trough levels can have a significant impact. When using exogenous T RBCs, hemoglobin and hematocrit will increase within the 1st month and can take anywhere from 9-12 months to reach peak levels. T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit). Other factors such as sleep apnea, smoking, asthma, COPD can have a negative impact on hematocrit. Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T. 3–18% with transdermal administration and up to 44% with injection. In most cases when using injectable T [U][B][I]high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)[/I][/B][/U] will have a big impact on increasing HCT. Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given. [B][I]As again [/I][/B][I][B]running very high TT/FT levels will have a stronger impact on driving up HCT.[/B][/I] Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that [I][B]the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.[/B][/I] Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels. [B][I]How high an FT level you are running is critical.[/I][/B] It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are [I][B]running too high an FT level[/B][/I][B][I].[/I][/B] Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such. If you are struggling with such blood markers then in most cases finding the[I][B] lowest FT level you can run while still maintaining the beneficial effects [/B][/I]may very well be the solution. Easier said than done as many men on trt tend to do better running higher-end FT levels within reason. Mind you some are lucky and never have an issue or levels tend to stabilize over time. Others will continue to struggle until the cows come home. Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
I am on week 5-6 anxiety comes and goes
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