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it's when e2 is very low but not crashed.. when it's absolutely crashed you loose all the water, you are not vascular anymore because your veins dissapear and basically you slowly turn in to 100 year old lady. your skin becomes dry, your hair becomes very dry, you are thristy as **** and constantly pissing out sodium and minerals making it impossible to rehydrate, testosterone isn't doing shit anymore because e2 is needed for testosterone to work so basically you feel hypogonadal even with normal androgen levels, lethargy, apathy, no joy in life and so on.. I had exact same thing as nurselyfe is going through right now. every time e2 goes up you have more and more low e2 symptoms for some reason.. It's like your e2 receptors don't react to e2 anymore.. the bad thing is there is no cure for this.. this is very similar as post finasteride syndrome but instead of insensitivity to dht it's insensitivty to e2.. people who had crashed e2 levles know how miserable they felt during that time but most normally recover but this situation is different.. you are not recovering but keep getting worse and more low e2 symptoms.. I have no idea if it's gonna get any better or no.Worst thing is nobody re****nizes this condition. 3 years post that crash I am still no better.. I don't even know if I ever will recover from this misery.. I also felt like I went backwards when I tried pregnenolone oral/cream.. Then I learned pregnenolone is also an aromatase inhibitor (https://raypeatforum.com/community/threads/pregnenolone-progesterone-and-androsterone-are-aromatase-inhibitors.3596/)..