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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
I accidentally took too much Arimidex...did I screw myself!?
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<blockquote data-quote="simeoni" data-source="post: 84694" data-attributes="member: 14463"><p>If I have understood correctly nurselyfe is mainly basing his theory in this animal study: <a href="http://www.sciencedirect.com/science/article/pii/0018506X81900180" target="_blank">http://www.sciencedirect.com/science/article/pii/0018506X81900180</a></p><p></p><p>Im not really sure if this backs up nurselyfe's theory. Here's what Im seeing from the full study:</p><p></p><p>- The rats with long term estrogen deprivation (35 days) did show a diminished response to combined estrogen and progesterone therapy. They did not show a similiar response in their behavioral patterns that was seen in the short term group - that was deprived for 5 days.</p><p></p><p>- They did not see a decrease in the number of E2 receptors. Decrease in progestin receptors was observed.</p><p></p><p>Here are few quotes from the full study: "Estrogen deprivation for a prolonged period (35 days) resulted in adecline in the effectiveness of subsequent estrogen treatment in activatingboth proceptive and receptive behaviors, and in stimulating cytoplasmicprogestin receptor in the PIT and POA-MBH. <em>This decline in the effectivenessof E, was not accompanied by a reduction in the amount ofestrogen receptor translocated into PIT and POA-MBH cell nuclei afterE, treatment."</em></p><p><em></em></p><p>"<em>One explanation for thereduced behavioral effect of combined E, and progesterone treatmentin long-term OVX animals might therefore be a decline in the effectivenessof estrogen in stimulating progestin receptor synthesis in the POAMBH</em>.The present results are consistent with this idea. However, itwould be premature to conclude that a change in the sensitivity of theprogestin receptor system is the only factor involved."</p><p></p><p>"<em>One explanation for thereduced behavioral effect of combined E, and progesterone treatmentin long-term OVX animals might therefore be a decline in the effectivenessof estrogen in stimulating progestin receptor synthesis in the POAMBH</em>.The present results are consistent with this idea. However, itwould be premature to conclude that a change in the sensitivity of theprogestin receptor system is the only factor involved."</p><p></p><p>"These observations indicate that other central nervous estrogen-dependentfactors, besides the induction of PR,, become desensitizedduring long-term estrogen deprivation. <em>The change in overall behavioralsensitivity to estrogen + progesterone therapy which occursafter gonadectomy probably reflects contributions from these factors aswell as from PR, synthesis.</em>"</p><p></p><p>Ok. So based on this rat study from 1981 there was an observable change in their behavior after a prolonged estrogen deprivation. From what I understand this study does not come to the conclusion that the cause of this was the desensitization of estrogen receptors.</p><p></p><p>Im not saying that it cannot happen. I would just like to know how does nurselyfe come to that conclusion based on <em>this study</em>?</p></blockquote><p></p>
[QUOTE="simeoni, post: 84694, member: 14463"] If I have understood correctly nurselyfe is mainly basing his theory in this animal study: [url]http://www.sciencedirect.com/science/article/pii/0018506X81900180[/url] Im not really sure if this backs up nurselyfe's theory. Here's what Im seeing from the full study: - The rats with long term estrogen deprivation (35 days) did show a diminished response to combined estrogen and progesterone therapy. They did not show a similiar response in their behavioral patterns that was seen in the short term group - that was deprived for 5 days. - They did not see a decrease in the number of E2 receptors. Decrease in progestin receptors was observed. Here are few quotes from the full study: "Estrogen deprivation for a prolonged period (35 days) resulted in adecline in the effectiveness of subsequent estrogen treatment in activatingboth proceptive and receptive behaviors, and in stimulating cytoplasmicprogestin receptor in the PIT and POA-MBH. [I]This decline in the effectivenessof E, was not accompanied by a reduction in the amount ofestrogen receptor translocated into PIT and POA-MBH cell nuclei afterE, treatment." [/I] "[I]One explanation for thereduced behavioral effect of combined E, and progesterone treatmentin long-term OVX animals might therefore be a decline in the effectivenessof estrogen in stimulating progestin receptor synthesis in the POAMBH[/I].The present results are consistent with this idea. However, itwould be premature to conclude that a change in the sensitivity of theprogestin receptor system is the only factor involved." "[I]One explanation for thereduced behavioral effect of combined E, and progesterone treatmentin long-term OVX animals might therefore be a decline in the effectivenessof estrogen in stimulating progestin receptor synthesis in the POAMBH[/I].The present results are consistent with this idea. However, itwould be premature to conclude that a change in the sensitivity of theprogestin receptor system is the only factor involved." "These observations indicate that other central nervous estrogen-dependentfactors, besides the induction of PR,, become desensitizedduring long-term estrogen deprivation. [I]The change in overall behavioralsensitivity to estrogen + progesterone therapy which occursafter gonadectomy probably reflects contributions from these factors aswell as from PR, synthesis.[/I]" Ok. So based on this rat study from 1981 there was an observable change in their behavior after a prolonged estrogen deprivation. From what I understand this study does not come to the conclusion that the cause of this was the desensitization of estrogen receptors. Im not saying that it cannot happen. I would just like to know how does nurselyfe come to that conclusion based on [I]this study[/I]? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
I accidentally took too much Arimidex...did I screw myself!?
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